Medicine for treating chemotherapy induced hand-foot syndromes and targeted therapy induced hand-foot skin reactions and preparation method thereof

A technology for targeted therapy and skin reaction, which is applied in the field of targeted therapy-induced hand-foot-skin reaction and chemotherapy-induced hand-foot syndrome, and can solve problems such as affecting the quality of life of patients, treatment interruption, and treatment effect.

Active Publication Date: 2016-09-21
CHINA JAPAN FRIENDSHIP HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the two are not life-threatening, once they occur, they will seriously affect the quality of life of the patient, causing the patient to be unable to engage in normal work or daily activities, and even lead to interruption of treatment, thus affecting the effect of treatment
Other treatments including topical cooling, vitamin B6, corticosteroids, DMSO, and supportive care and patient education have not been satisfactory

Method used

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  • Medicine for treating chemotherapy induced hand-foot syndromes and targeted therapy induced hand-foot skin reactions and preparation method thereof
  • Medicine for treating chemotherapy induced hand-foot syndromes and targeted therapy induced hand-foot skin reactions and preparation method thereof
  • Medicine for treating chemotherapy induced hand-foot syndromes and targeted therapy induced hand-foot skin reactions and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0041] Preparation Example 1: Preparation of Powder

[0042] Take the raw materials according to the following weight ratio:

[0043] Astragalus 15Kg Safflower 10Kg Geranium 15Kg Comfrey 10Kg Angelica 12Kg

[0044] Preparation:

[0045] Astragalus and Angelica were decocted twice with water, each time with 10 times the amount of Astragalus and Angelica, and decocted for 1.5 hours each time. The extracts were combined and concentrated under reduced pressure to obtain Clear Paste 1 with a relative density of 1.24 at 50°C. Geranium and Comfrey were extracted twice with 75wt% ethanol aqueous solution, each time the amount of ethanol aqueous solution was 15 times and 12 times of the weight of Geranium and Comfrey respectively, the temperature was 60°C, each extraction was 1.5 hours, and the extracts were combined , to obtain the extract 1. The safflower was extracted twice with 50wt% ethanol aqueous solution, each time the amount of ethanol aqueous solution was 12 times and 10 t...

preparation Embodiment 2

[0046] Preparation Example 2: Preparation of Granules

[0047] Take the raw materials according to the following weight ratio:

[0048] Astragalus 10Kg Safflower 5Kg Angelica 10Kg

[0049] Geranium 10Kg Comfrey 10Kg

[0050] Preparation:

[0051] Astragalus and Angelica were decocted twice with water, each time with 10 times the amount of Astragalus and Angelica, and decocted for 1 hour each time. The extracts were combined and concentrated under reduced pressure to obtain Clear Paste 1 with a relative density of 1.22 at 55°C. Geranium and Comfrey were extracted twice with 80wt% ethanol aqueous solution, each time the amount of ethanol aqueous solution was 15 times and 12 times of the weight of Geranium and Comfrey respectively, the temperature was 60°C, each extraction was 1 hour, and the extracts were combined , to obtain the extract 1. The safflower was extracted twice with 55wt% ethanol aqueous solution, each time the amount of ethanol aqueous solution was 12 times and 1...

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Abstract

The invention provides a medicine for treating chemotherapy induced hand-foot syndromes and targeted therapy induced hand-foot skin reactions and a preparation method thereof. The medicine is prepared from aqueous extract of 5-60 parts by weight of milkvetch roots and 5-30 parts by weight of radix angelica sinensis, extract of 5-30 parts by weight of herba geranii and 5-30 parts by weight of radix arnebiae seu lithospermi, and 45-55wt% ethyl alcohol water solution extract of 5-30 parts by weight of safflower. The medicine for treating chemotherapy induced hand-foot syndromes and targeted therapy induced hand-foot skin reactions has the functions of tonifying qi and promoting blood circulation and removing toxins and promoting granulation, and can achieve the satisfactory effect of effectively treating chemotherapy induced hand-foot syndromes and targeted therapy induced hand-foot skin reactions.

Description

technical field [0001] The invention relates to a medicine for treating chemotherapy-induced hand-foot syndrome and targeted therapy-induced hand-foot skin reaction, in particular to a medicine for treating chemotherapy-induced hand-foot syndrome and targeted therapy-induced hand-foot skin reaction made from Chinese herbal medicines . Background technique [0002] The incidence of malignant tumors is increasing year by year, and new chemotherapy drugs and targeted drugs are increasingly widely used in clinical tumors. While improving the anti-tumor efficacy, many new adverse reactions have emerged, which have become clinical refractory complications of tumors. Chemotherapy drugs represented by capecitabine, liposomal doxorubicin and pentafluorouracil (5-Fu) Hand-foot syndrome (hand-foot syndrome, HFS), sorafenib, suni Hand-foot syndrome skin reaction (HFSR) caused by targeted drugs represented by tinib is a common adverse reaction in tumor clinical practice. The effective ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61P17/00A61P39/02
CPCA61K36/185A61K36/232A61K36/286A61K36/30A61K36/481A61K2236/331A61K2236/333A61K2236/51A61K2300/00
Inventor 贾立群娄彦妮刘猛邓博
Owner CHINA JAPAN FRIENDSHIP HOSPITAL
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