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Patient-specific analysis of positron emission tomography data

A technology of positron emission and tomography, applied in the field of medical imaging, which can solve problems such as poor repeatability

Inactive Publication Date: 2016-09-28
理查德 R 布莱克
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Problems solved by technology

Such a qualitative approach is subjective and may be poorly reproducible

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  • Patient-specific analysis of positron emission tomography data
  • Patient-specific analysis of positron emission tomography data
  • Patient-specific analysis of positron emission tomography data

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[0015] A widely used SUV threshold for classification of neoplastic and non-neoplastic diseases is considered to be 2.5. However, it has been suggested that different thresholds for malignant disease designation are based on the location involved, such that a commonly used value of 2.5 may be associated with an overall decrease in specificity. To further complicate the use of SUV in the evaluation of individuals with suspected malignancy, inter-individual and intra-individual variation in SUV can occur on the same imaging device. Performing a series of examinations on the same patient using different devices further increases inconsistency and reduces the overall accuracy of individual examinations.

[0016] According to one aspect of the present invention, systems and methods for patient-specific analysis of positron emission tomography (PET) images are provided. Specifically, the inventors have determined that the stability of glucose uptake in the liver can be used to prov...

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Abstract

Systems and methods are provided for evaluating tissue for abnormal glucose uptake within a region of interest within a patient. A PET scanner obtains PET imagery including the region of interest and at least part of the liver. An SUV calculator calculates a first set of SUVs representing the region of interest and a second set SUVs representing the liver from the set of at least one PET image. A standardization component calculates a correction value as a function of the second set of SUVs and applies the correction value to either a decision threshold associated with the region of interest or the first set of SUVs. A diagnosis component compares the first set of SUVs to the decision threshold to determine if the glucose uptake within the region of interest is abnormal. A display provides the determination to a user.

Description

[0001] related application [0002] This application claims U.S. Provisional Patent Application Serial No. 62 / 054,661, filed September 24, 2014, U.S. Provisional Patent Application Serial No. 61 / 984,246, filed April 25, 2014, and Priority to each of U.S. Provisional Patent Application Serial No. 61 / 882,261 filed on March 25. Each of these applications is incorporated herein by reference. technical field [0003] The present invention relates to medical imaging, and more particularly to patient-specific analysis of positron emission tomography data. Background technique [0004] Early diagnosis, appropriate presentation, and subsequent evaluation of treatment outcomes for various malignancies can be enhanced by modern imaging techniques. In 1956, Warburg proposed that many malignant cells utilize anaerobic consumption of pyruvate-glucose as the main source of energy. Twenty years later, Bustamonte et al suggested that since glucose metabolism in malignant cells could exce...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B6/00A61K49/00G01T1/161
CPCA61B6/032A61B6/037A61B6/50A61B6/5205A61B6/5217G16H50/30
Inventor 理查德·R·布莱克
Owner 理查德 R 布莱克
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