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A kind of method that mechanical force prepares curcumin nanoparticle transparent suspension

A mechanical force, nanoparticle technology, applied in the field of nanomaterials, can solve the problems of curcumin insoluble in water, low bioavailability, easy to be metabolized, etc., and achieve uniform particle size, simple preparation process, and high yield. Effect

Active Publication Date: 2019-02-22
SHANDONG LVSEN WOOD PLASTIC COMPOSITE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] It has a wide range of pharmacological effects in anti-cancer and wound healing; anti-cancer is one of the main pharmacological activities of curcumin, and its tumor-inhibiting effect has been repeatedly confirmed in many animal experiments. The specific anti-cancer mechanism has become a research hotspot, and It is listed as the third-generation cancer chemoprevention drug; but curcumin is insoluble in water, poor in stability, easily metabolized, and low in bioavailability. Hotspots in element research

Method used

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  • A kind of method that mechanical force prepares curcumin nanoparticle transparent suspension
  • A kind of method that mechanical force prepares curcumin nanoparticle transparent suspension

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Preparation of polyvinylpyrrolidone K30 aqueous solution: use an electronic balance to accurately weigh 6 g of polyvinylpyrrolidone K30 into a beaker, add 600 ml of deionized water, stir for 2 minutes with a magnetic stirrer, and the polyvinylpyrrolidone K30 is completely dissolved.

[0038] Preparation of curcumin / polyvinylpyrrolidone K30 mixed suspension: use an electronic balance to accurately weigh 6 g of curcumin and add it to the above polyvinylpyrrolidone K30 aqueous solution, and stir for 1 minute by using a glass rod.

[0039] Preparation of transparent suspension of curcumin nanoparticles by mechanical force: (1) Use IKA high-speed disperser to pre-disperse the mixed suspension prepared above. Grade curcumin nanoparticle suspension; (2) Use a stone mortar grinder to grind the above-mentioned pre-dispersed suspension, the speed of the grinder is 1500r / min, the scale is at -0.2mm, and grind for 5 minutes; (3) Put the suspension after the grinding treatment above...

Embodiment 2

[0042] Preparation of polyvinylpyrrolidone K30 aqueous solution: use an electronic balance to accurately weigh 6 g of polyvinylpyrrolidone K30 into a beaker, add 600 ml of deionized water, stir for 2 minutes with a magnetic stirrer, and the polyvinylpyrrolidone K30 is completely dissolved.

[0043] Preparation of curcumin / polyvinylpyrrolidone K30 mixed suspension: use an electronic balance to accurately weigh 6 g of curcumin and add it to the above polyvinylpyrrolidone K30 aqueous solution, and use a glass rod to stir for 3 minutes to preliminarily disperse curcumin in the aqueous solution.

[0044] Prepare curcumin nanoparticle transparent suspension by mechanical force: (1) use IKA high-speed disperser to pre-disperse the mixed suspension prepared above, the speed of IKA high-speed disperser is 10000r / min, pre-disperse for 3 minutes; Micron-sized curcumin nanoparticle suspension; (2) use a stone mortar grinder to grind the above-mentioned pre-dispersed suspension, the speed o...

Embodiment 3

[0047] Preparation of polyvinylpyrrolidone K30 aqueous solution: use an electronic balance to accurately weigh 3g of polyvinylpyrrolidone K30 into a beaker, add 800ml of deionized water, stir for 3 minutes with a magnetic stirrer, and the polyvinylpyrrolidone K30 is completely dissolved.

[0048] Preparation of curcumin / polyvinylpyrrolidone K30 mixed suspension: use an electronic balance to accurately weigh 6 g of curcumin and add it to the above polyvinylpyrrolidone K30 aqueous solution, and stir the curcumin in the aqueous solution by using a glass rod.

[0049] Prepare curcumin nanoparticle transparent suspension by mechanical force: (1) Use IKA disperser to pre-disperse the mixed suspension prepared above, the speed of IKA high-speed disperser is 8000r / min, pre-disperse for 5 minutes; (2) Use a stone mortar grinder to grind the above-mentioned pre-dispersed suspension, the speed of the grinder is 1500r / min, the scale is -0.15mm, grind for 10 minutes, and get a preliminary n...

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Abstract

The invention provides a method for preparing a curcumin nano-particle transparent suspension through a mechanical acting force. The method comprises the following processing steps of preparing a polyvinylpyrrolidone K30 aqueous solution, preparing a curcumin and polyvinylpyrrolidone K30 mixed suspension and preparing the curcumin nano-particle transparent suspension through the mechanical acting force. The method for preparing the curcumin non-particle transparent suspension through the mechanical acting force has the advantages that the particle sizes of curcumin nano-particles in the curcumin nano-particle transparent suspension range from 25 nm to 50 nm, the particle size is small, and the particles are uniform in size; the prepared curcumin nano-particles can be uniformly dispersed in the aqueous solution, and the stability of curcumin is improved; the curcumin nano-particle transparent suspension is prepared through a pure physical method, the preparation technology is simple, no chemical treatment is adopted, and the molecular structure of the curcumin can not be affected; the prepared curcumin nano-particle transparent suspension is high in yield and less in waste of the curcumin raw material.

Description

technical field [0001] The invention relates to a method for preparing a transparent suspension of curcumin nanoparticles by mechanical force, and belongs to the field of nanomaterials. Background technique [0002] Curcumin is the main active compound in the plant turmeric. It is an orange-yellow crystalline powder. It has been used in the food industry as a spice, food coloring agent and nutritional supplement; , antibacterial, [0003] It has a wide range of pharmacological effects in anti-cancer and wound healing; anti-cancer is one of the main pharmacological activities of curcumin, and its tumor-inhibiting effect has been repeatedly confirmed in many animal experiments. The specific anti-cancer mechanism has become a research hotspot, and It is listed as the third-generation cancer chemoprevention drug; but curcumin is insoluble in water, poor in stability, easily metabolized, and low in bioavailability. Hotspots in element research. [0004] Polyvinylpyrrolidone K3...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K31/12A61K47/32A61P35/00
CPCA61K9/10A61K31/12A61K47/32
Inventor 李大纲刘婷马自超王慧敏熊家玉
Owner SHANDONG LVSEN WOOD PLASTIC COMPOSITE
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