Application of plukenetia volubilis linneo leaf extract to preparation of hypoglycemic medicines

A technology of saiteng fruit and extract, which is applied in the field of application of saiteng fruit leaf extract in the preparation of hypoglycemic drugs, can solve the problems of stimulating insulin secretion, improving body sensitivity, hypoglycemic liver, etc., and achieves stable and stable efficacy , the method is flexible, and the effect of avoiding the sequelae of diabetes

Inactive Publication Date: 2016-11-09
杜冰 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicines such as sulfonylureas, biguanides, insulin, and glycosidase inhibitors are mainly used to stimulate insulin secretion, improve body sensitivity, and slow down sugar conversion and absorption; however, Western medicines often have side effects, the most common side effects being hypoglycemia and damage to the liver

Method used

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  • Application of plukenetia volubilis linneo leaf extract to preparation of hypoglycemic medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: Sateng fruit leaf water extract

[0018] Take 10Kg of dried leaves of Sateng fruit, wash them with water, add 10 times the weight of water, soak for 1 hour, heat and boil for 3 hours, filter, concentrate the filtrate to 20°C when the relative density reaches 1.3, and spray the concentrated solution to obtain dry fine Powder 1.25Kg.

Embodiment 2

[0019] Example 2: Combination (water+ethanol) extracts of Satoshi fruit leaves

[0020] Take 10Kg of dry leaves of Sateng fruit, wash them with water, add 8 times the weight of water, soak for 1 hour, heat and boil for 3 hours, filter, and concentrate the filtrate to 20 °C when the relative density reaches 1.2, and use 8 times the weight of the concentrated solution to 80% Ultrasonic extraction with ethanol for 2 hours, filtration, combined filtrates, and freeze-drying to obtain 0.65Kg of dry matter.

Embodiment 3

[0021] Embodiment 3. The pharmacodynamic experiment of embodiment 1

[0022] Diabetic mouse experiment to investigate the hypoglycemic effect of the extract

[0023] The conventional hypoglycemic drug glibenclamide was used as a positive control, and the hypoglycemic effect of the water extract of Sateng fruit leaves was studied by conducting glucose tolerance test (GTT) and hypoglycemic treatment test on normal mice and diabetic mice. The results showed that the 50mg / kg·BW dosage group could significantly reduce the blood sugar level of the mice, and control the blood sugar level of the mice within the normal range, especially in the range of 1-3h after administration, its effect was better than that of glibenclamide ; It shows that the water extract of saiteng fruit leaves can significantly improve the symptoms of hyperglycemia in diabetic mice, and has a good hypoglycemic effect. The effect of the water extract of saiteng fruit leaves on the blood sugar level of diabetic m...

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Abstract

The invention discloses an application of a plukenetia volubilis linneo leaf extract to preparation of hypoglycemic medicines. An extraction method of the plukenetia volubilis linneo leaf extract comprises the following steps: taking plukenetia volubilis linneo leaves, adding a solvent, carrying out decoction and extraction, filtering an extracting solution and carrying out concentration. The effects of the plukenetia volubilis linneo leaves are focused, and the natural plant extract is adopted, thus avoiding the toxic and side effects of western medicines on human bodies. The extraction method is simple and practicable and is flexible in mode. The plukenetia volubilis linneo leaf extract belongs to plant extracts, has stable and gentle effects, does not have obvious toxic or side effect temporarily and avoids the defect that the traditional western medicines intensify the sequelae of diabetes mellitus while giving play to the hypoglycemic effects. Mice tests are carried out on the plukenetia volubilis linneo leaf extract and the research results show that 50mg / kg.BW dose of plukenetia volubilis linneo leaf extract has the effect of obviously reducing the blood glucose levels of human bodies, inferring that the plukenetia volubilis linneo leaves contain hypoglycemic functional components.

Description

technical field [0001] The present invention relates to the leaves of Sateng fruit, in particular to the application of the extract from the leaves of Sateng fruit in the preparation of hypoglycemic drugs. Background technique [0002] Sagittarius, belonging to Euphorbiaceae, is a perennial woody vine plant. It was introduced from South America to my country in 2006 and then planted in Hainan, Yunnan, Guangxi and other places. In 2013, the Ministry of Health of my country approved Miteng oil as a new resource. food. The leaves are papery alternate leaves, nearly ovate or broadly heart-shaped, 9-15 cm long, 6-10 cm wide; apex acuminate or short-tailed, base nearly truncated, margin crenate or irregular Serrated, glandular. At present, there is no report about the extract of leaves of Sateng fruit. [0003] The normal value of fasting blood glucose is below 6.1mmol / L, and the normal value of blood glucose two hours after a meal is below 7.8mmol / L. If it is higher than this r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/47A61P3/10
CPCA61K36/47A61K2236/33A61K2236/331A61K2236/333
Inventor 杜冰陈军谢蓝华陈曦梁钻好代文豪
Owner 杜冰
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