Application of Plukenetia volubilis husk extract in preparation of blood pressure lowering medicines
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An extract, the technology of saiteng fruit, applied in the field of application of saiteng husk extract, can solve the problems of damage to human organs, failure to block complications, and aggravate complications, so as to avoid diabetes sequelae and the extraction method is simple and easy line, to avoid the effect of side effects
Active Publication Date: 2016-10-26
杜冰 +1
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Problems solved by technology
Although western medicine lowers blood pressure quickly, it can treat the symptoms but not the root cause, because it cannot inhibit the deterioration of the disease, not only cannot block the complications, but will aggravate the occurrence of complications
This is because a large number of drug metabolism toxins produced by antihypertensive drugs will be deposited on the blood vessel wall, and the more they are taken, the more they will be deposited, which will eventually lead to hardening, thinning, and brittle blood vessels; Rapid blood pressure reduction by dilating blood vessels by force will inevitably make the hardened blood vessels more fragile, which will seriously damage important human organs such as the heart, brain, liver, and kidneys, and aggravate the occurrence of complications , ultimately endangering human life
For example, the commonly used antihypertensive drug Captopril has side effects such as rash, itching, fatigue, dizziness, nausea, severe cough, and abnormal taste
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Embodiment 1
[0018] Embodiment 1: the water extract of sargassum husk
[0019] Take 10Kg of dry fruit husks, wash with water, add 10 times the weight of water, soak for 1 hour, heat and boil for 2 hours, filter, add 6 times the weight of water to the filter residue, boil for 2 hours, filter, combine the filtrate, and concentrate the filtrate to The relative density reaches 1.3 at 20°C, and the concentrated solution is spray-dried to obtain 1.03Kg dry fine powder.
Embodiment 2
[0020] Example 2: Satoshi husk combination (water+ethanol) extract
[0021] Take 20Kg of dry fruit husk, wash with water, add 8 times the weight of water, soak for 1 hour, heat and boil for 3 hours, filter, concentrate the filtrate to 20°C when the relative density reaches 1.2, and freeze-dry the concentrate. Take 0.5Kg of the dry fine powder (about 100 mesh) prepared above, ultrasonically extract with 8 times the weight (W / W) of 80% ethanol for 3 hours, filter, combine the filtrates, and freeze-dry to obtain 0.05Kg of dry matter.
Embodiment 3
[0022] The pharmacodynamic test of embodiment 3. embodiment 1
[0023] Experiments on hypertensive mutant rats to investigate the antihypertensive effect of the extract
[0025] Test method: Rats were given intragastric volume of 1ml / 100g, the concentration of captopril was 0.5mg / mL, and the dose of sargassum husk extract was 40mg / mL.
[0026] The results showed that the husk extract of Satoshi berries had a significant effect of lowering blood pressure (the effect of lowering blood pressure could be shown after 0.5h). Thus it is shown that the saponica husk extract contains antihypertensive functional components.
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Abstract
The invention discloses an application of a Plukenetia volubilis husk extract in preparation of blood pressure lowering medicines. An extraction method for the Plukenetia volubilis husk extract comprises the following steps of crushing Plukenetia volubilis husks, adding a solvent into the crushed Plukenetia volubilis husks, carrying out decocting extraction, filtering out the husks, filtrating an extracting solution, and carrying out concentration, thereby preparing the Plukenetia volubilis husk extract. According to the application, the natural plant extract is adopted, so that toxic or side effects on human bodies caused by Western medicines such as captopril are avoided. The extraction method is easy and feasible and is flexible in manner. Through carrying out an intragastric administration test on rats by using the Plukenetia volubilis husk extract, a research result shows that the Plukenetia volubilis husk extract has a remarkable blood pressure lowering effect, so that the condition that the Plukenetia volubilis husks contain blood pressure lowering functional components is deduced. The Plukenetia volubilis husk extract belongs to plant extracts and is stable and mild in effect, no obvious toxic or side effects is discovered at present, and the abuse of the traditional Western medicines that sequelae of diabetes are aggravated is avoided while the Plukenetia volubilis husk extract plays a role in lowering blood pressure.
Description
technical field [0001] The present invention relates to saiteng fruit, in particular to the application of saiteng fruit husk extract. Background technique [0002] Sagittarius, belonging to the Euphorbiaceae genus Sagittarius, is a perennial woody vine plant, which is currently mainly planted in Southwest my country. In 2013, the Ministry of Health of my country approved sachaeto fruit oil as a new resource food. At the present stage, the utilization method of saiteng fruit is mainly to take the nuts for extracting saiteng fruit oil and processing related end products. At present, there is no report about the extract of sachaetra vine husk. [0003] Hypertension is a clinical syndrome characterized by increased systemic arterial blood pressure, which may be accompanied by functional or organic damage to the heart, brain, kidney and other organs. It is the most common chronic disease and the most important risk factor for cardiovascular and cerebrovascular diseases. Altho...
Claims
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Application Information
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