Application of Satoshi husk extract in the preparation of antihypertensive drugs
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An extract, the technology of saiteng fruit, applied in the field of application of saiteng husk extract, can solve the problems of damage to human organs, failure to block complications, and aggravate complications, so as to avoid diabetes sequelae and the extraction method is simple and easy line, to avoid the effect of side effects
Active Publication Date: 2020-02-07
杜冰 +1
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Summary
Abstract
Description
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Problems solved by technology
Although western medicine lowers blood pressure quickly, it can treat the symptoms but not the root cause, because it cannot inhibit the deterioration of the disease, not only cannot block the complications, but will aggravate the occurrence of complications
This is because a large number of drug metabolism toxins produced by antihypertensive drugs will be deposited on the blood vessel wall, and the more they are taken, the more they will be deposited, which will eventually lead to hardening, thinning, and brittle blood vessels; Rapid blood pressure reduction by dilating blood vessels by force will inevitably make the hardened blood vessels more fragile, which will seriously damage important human organs such as the heart, brain, liver, and kidneys, and aggravate the occurrence of complications , ultimately endangering human life
For example, the commonly used antihypertensive drug Captopril has side effects such as rash, itching, fatigue, dizziness, nausea, severe cough, and abnormal taste
Method used
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Examples
Experimental program
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Effect test
Embodiment 1
[0018] Example 1: Water extract of Mei Teng husk
[0019] Take 10Kg of dried fruit husks, wash with water, add 10 times the weight of water, soak for 1 hour, heat and boil for 2 hours, filter, add 6 times the weight of water to the residue, boil for 2 hours, filter, combine the filtrate, and concentrate the filtrate to The relative density reaches 1.3 at 20°C, and the concentrated solution is spray-dried to obtain 1.03Kg of dry fine powder.
Embodiment 2
[0020] Example 2: Extract from the Husk Combination (Water+Ethanol) of Mei Teng
[0021] Take 20Kg of dried fruit husks, wash with water, add 8 times the weight of water, soak for 1 hour, heat and boil for 3 hours, filter, concentrate the filtrate to 20°C when the relative density reaches 1.2, and freeze-dry the concentrate. Take 0.5Kg of the above-prepared dry powder (about 100 mesh), use 8 times the weight (W / W) 80% ethanol to ultrasonically extract for 3 hours, filter, combine the filtrate, freeze-dry to obtain a dry product 0.05Kg.
Embodiment 3
[0022] Example 3. Pharmacodynamic test of Example 1
[0023] Experiment on hypertensive mutant rats to investigate the antihypertensive effect of the extract
[0025] Test method: The intragastric administration volume of rats was 1ml / 100g, the concentration of captopril was 0.5mg / mL, and the dose of M. vine husk extract was 40mg / mL.
[0026] The results show that the extract from the husk of the vine fruit has a significant effect on lowering blood pressure (the effect can be lowered after 0.5h). This indicates that the husk extract of Mei Teng contains functional components for reducing blood pressure.
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Abstract
The invention discloses an application of a Plukenetia volubilis husk extract in preparation of blood pressure lowering medicines. An extraction method for the Plukenetia volubilis husk extract comprises the following steps of crushing Plukenetia volubilis husks, adding a solvent into the crushed Plukenetia volubilis husks, carrying out decocting extraction, filtering out the husks, filtrating an extracting solution, and carrying out concentration, thereby preparing the Plukenetia volubilis husk extract. According to the application, the natural plant extract is adopted, so that toxic or side effects on human bodies caused by Western medicines such as captopril are avoided. The extraction method is easy and feasible and is flexible in manner. Through carrying out an intragastric administration test on rats by using the Plukenetia volubilis husk extract, a research result shows that the Plukenetia volubilis husk extract has a remarkable blood pressure lowering effect, so that the condition that the Plukenetia volubilis husks contain blood pressure lowering functional components is deduced. The Plukenetia volubilis husk extract belongs to plant extracts and is stable and mild in effect, no obvious toxic or side effects is discovered at present, and the abuse of the traditional Western medicines that sequelae of diabetes are aggravated is avoided while the Plukenetia volubilis husk extract plays a role in lowering blood pressure.
Description
Technical field [0001] The present invention relates to vine fruit, in particular to the application of vine husk extract. Background technique [0002] Meiteng fruit, belonging to the genus Meiteng fruit of the Euphorbiaceae family, is a perennial woody vine, currently mainly grown in southwest my country. In 2013, the Ministry of Health of the People's Republic of my country approved Mei Teng Fruit Oil as a new resource food. At the present stage, the main method of Utilization of Miteng fruit is to take the nuts to extract Miteng fruit oil and process related end products. The shell of Miteng fruit left after shelling cannot be used. There is no report about the extract of M. vine husk. [0003] Hypertension is a clinical syndrome characterized by increased systemic arterial blood pressure, which can be accompanied by functional or organic damage to the heart, brain, kidney and other organs. It is the most common chronic disease and the most important risk factor for cardiovas...
Claims
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Application Information
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