Preparation technology of phenylboronic acid reaction liquid
A technology of reaction solution and phenylboric acid, which is applied in the field of preparation technology of reaction solution, can solve the problems of complex preparation process of phenylboric acid and is not suitable for mass production operations, and can meet the needs of mass production, the preparation process cycle is short, and the process Simple process effect
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[0011] In order to make the purpose, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below; it should be understood that the specific implementations described here are only used to explain the present invention, and are not intended to limit the present invention.
[0012] This specific embodiment adopts following technical scheme: its preparation method is:
[0013] Step 1: Under nitrogen protection, add 540g of anhydrous tetrahydrofuran to the reaction flask, start stirring, add 30g of iodobenzene, and cool to -78°C;
[0014] Step 2: Slowly add 86g of n-BuLi (2.0M) dropwise, stir at -78°C for 1.0hr, slowly and naturally rise to 30-40°C to keep warm, and react for 4.0hr;
[0015] Step 3: Cool the reaction solution to below -78°C again, slowly add 77g of triisopropyl borate dropwise, stir for 0.5hr, slowly rise to room temperature, and stir overnight;
[0016] Step 4: Add 540g of 1N hydrochloric a...
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