Melatonin preparation for improving sleeping and preparation method thereof

A technology for improving sleep and melatonin, applied in pill delivery, pharmaceutical formulations, coatings, etc., can solve problems such as poor taste, and achieve the effects of prolonging sleep time, shortening sleep latency, and taking less dosage

Inactive Publication Date: 2016-11-23
广州联存医药科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many varieties of sleep-improving products on the market, most of which are Chinese patent medicine ingredients, and melatonin is used as a raw material. There are fewer varieties, and the dosage forms include oral liquid, capsules, tea, tablets, etc., and the taste is poor.

Method used

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  • Melatonin preparation for improving sleeping and preparation method thereof
  • Melatonin preparation for improving sleeping and preparation method thereof
  • Melatonin preparation for improving sleeping and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: Preparation of melatonin preparation A for improving sleep

[0018] The sleep-improving melatonin preparation of the present embodiment comprises the following raw materials: 3kg of melatonin, 150kg of starch, 128kg of white granulated sugar, 110kg of dextrin, 4kg of talcum powder, 4kg of magnesium stearate, 1kg of sodium carboxymethylcellulose and Film coating agent 10.6kg.

[0019] The preparation method of the melatonin preparation A that improves sleep (as figure 1 shown), including the following steps:

[0020] Step 1) take the melatonin, starch, white granulated sugar and dextrin of formula quantity and pulverize and pass through a 100 mesh sieve; weigh the talcum powder and magnesium stearate of formula quantity and pulverize and pass through a 40 mesh sieve for subsequent use;

[0021] Step 2) Add the sodium carboxymethyl cellulose of the formula amount into purified water, heat to 50-60 ° C, stir until the sodium carboxymethyl cellulose is compl...

Embodiment 2

[0030] Embodiment 2: Preparation of melatonin preparation B for improving sleep

[0031] The sleep-improving melatonin preparation of the present embodiment includes the following raw materials: 1 kg of melatonin, 130 kg of starch, 120 kg of white granulated sugar, 144 kg of dextrin, 5 kg of talcum powder, 2 kg of magnesium stearate, and 0.5 kg of sodium carboxymethyl cellulose And film coating agent 8kg.

[0032] The preparation method of the sleep-improving melatonin preparation B is the same as that of Example 1.

[0033] The formula of the film coating agent of the present embodiment is identical with the formula of embodiment 1.

Embodiment 3

[0034] Embodiment 3: the preparation of the melatonin preparation C that improves sleep

[0035] The sleep-improving melatonin preparation of the present embodiment comprises the following raw materials: melatonin 2kg, starch 170kg, white granulated sugar 150kg, dextrin 70kg, talcum powder 2kg, magnesium stearate 4kg, sodium carboxymethylcellulose 2kg and Film coating agent 12kg.

[0036] The preparation method of the sleep-improving melatonin preparation C is the same as that of Example 1.

[0037] The formula of the film coating agent of the present embodiment is identical with the formula of embodiment 1.

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Abstract

The invention discloses a melatonin preparation for improving sleeping and a preparation method thereof. The melatonin preparation is prepared from the following raw materials in parts by weight: 1 to 3 parts of melatonin, 130 to 170 parts of starch, 100 to 156 parts of white granulated sugar, 70 to 144 parts of dextrin, 2 to 6 parts of talcum powder, 2 to 6 parts of magnesium stearate and 0.2 to 2 parts of sodium carboxymethylcellulose. The melatonin preparation for improving sleeping has the characteristics of safety, no toxicity, good taste, less dose and no dependence. Tests show that the melatonin preparation has the advantages that the sleeping time of nembutal can be obviously extended, the hypnotic effect of subthreshold dose of the nembutal is cooperated, the sleep latency of the nembutal is shortened, and a function of obviously improving sleeping is realized.

Description

Technical field: [0001] The invention belongs to the technical field of health product production, and in particular relates to a melatonin preparation for improving sleep and a preparation method thereof. Background technique: [0002] About one-third of a person's life is spent in sleep, and the quality of sleep is closely related to health. Medical research shows that occasional insomnia can lead to fatigue and uncoordinated movements the next day, and long-term insomnia can lead to consequences such as inability to concentrate, memory impairment, and inability to work. And the ability to recover is reduced, often prone to colds, and may aggravate other diseases or induce the original disease. [0003] At present, there are many varieties of sleep-improving products on the market, most of which are Chinese patent medicine components, and melatonin-based varieties are less, and the dosage forms include oral liquids, capsules, teas, tablets, etc., and the taste is poor. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4045A61K9/36A61P25/20
CPCA61K31/4045A61K9/2866
Inventor 蒋健强
Owner 广州联存医药科技股份有限公司
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