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Novel medical sponge stent material with collagen combined with calcium phosphate and preparation method

A technology of calcium phosphate and tricalcium phosphate, applied in medical science, prosthesis, etc., can solve problems such as high hardness, difficult to shape cartilage, and osteochondral damage

Inactive Publication Date: 2016-11-23
TIANJIN SANNIE BIOENG TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently clinically used collagen-bonded calcium phosphate (abbreviated as collagen / calcium phosphate) bone repair scaffold has a good effect on the repair of dense bone, but it is not suitable for repairing cartilage, including osteochondral damage, due to its high hardness and difficulty in shaping.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0013] Weigh 15g of collagen powder, add 1000ml of pure water for injection to dissolve and make a 1.5% solution, and adjust the pH value to 3.8 with acetic acid. Divide into quarters by volume. Vacuum pumping rate removes air bubbles. In the first part, HA with a particle size of 0.3 mm accounts for 75% of the weight ratio of collagen / HA. The stirrer was stirred at a low speed of 500 rpm until a uniform HA suspension was formed, and the stirring was continued for several hours to make it swell into a colloid. Gently pour the collagen / HA colloid containing HA with a particle size > 0.3mm into a container, and gently pour the collagen / HA colloid with a particle size of 0.1-0.3mm HA on it, followed by the ones with a particle size < 0.1mm HA collagen / HA colloid, and HA-free collagen solution. Quickly place the container at -20°C to freeze solid. Vacuum freeze-drying obtains a semi-solid collagen sponge scaffold, apparently with high hardness at one end and high elasticity at...

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PUM

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Abstract

The invention discloses a novel medical sponge stent material with collagen and calcium phosphate as raw materials and a preparation method, provides a novel medical sponge stent material with collagen combined with calcium phosphate and a preparation method, and belongs to the technical field of biomedical materials. The problem that in osteochondral injury treatment at present, repair of cartilage tissue and infusion of the cartilage tissue to be repaired and a compact bone part (namely, a hard bone part) connected with the cartilage tissue can not be carried out at the same time is solved, and the defect that a present clinical collagen / calcium phosphate bone repair material can not well repair osteochondral tissue injury is overcome.

Description

technical field [0001] The invention relates to a novel material and a preparation method of a collagen-bound calcium phosphate medical sponge support, and the prepared collagen sponge support can be used to repair bone cartilage tissue damage. Background technique [0002] Disease or trauma can cause damage to the cartilage layer of human bones (also known as osteochondral), which can be used clinically to repair or regenerate damaged cartilage tissue by implanting cartilage-like substitutes, especially with biocompatibility and biodegradability Sexual collagen. Collagen as a scaffold can induce the cells that promote the growth of blood vessels and nerve tissue to attach, migrate and grow at the site of cartilage injury, thereby promoting the regeneration of cartilage tissue. Calcium phosphate is the main inorganic phase chemical component of bone tissue, especially hydroxyapatite (chemical formula Ca 5 (PO 4 ) 3 OH, English hydroxyapatite, abbreviated as HA) and β-tri...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/24A61L27/50
Inventor 毕宏伟杜宪明
Owner TIANJIN SANNIE BIOENG TECH
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