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Suture line applicable to operation of biliary tract and preparation method thereof

A technology for biliary tract surgery and sutures, applied in the field of medical devices, can solve the problems that sutures cannot be absorbed by the human body, have poor compatibility, and are not ideal, so as to avoid the regeneration of stones, reduce the pain of patients, and improve the prognosis.

Inactive Publication Date: 2016-12-07
LINYI YISHUI CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the performance of the existing surgical sutures in this aspect is not ideal. The sutures are not compatible with the human body or the sutures caused by other reasons cannot be absorbed by the human body, and stones will be formed again centered on the residual sutures, which is a serious problem for patients. cause pain

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A method for preparing suture thread suitable for biliary tract surgery includes the following steps:

[0027] (1) Preparation of spinning solution: Dissolve chitosan in an acetic acid solution with a mass concentration of 2%, add sodium hyaluronate and polyvinyl alcohol in sequence, stir for 3 hours, then add collagen, continue stirring for 10 hours, and filter , Remove air bubbles under vacuum conditions to obtain a spinning solution; wherein the mass ratio of chitosan, acetic acid solution, sodium hyaluronate, polyvinyl alcohol and collagen is 3:85:2:4:2;

[0028] (2) Spinning: The spinning solution is fed into the spinneret with a metering pump, and the spinning solution is squeezed into the coagulation bath while being coagulated and stretched to obtain a thread;

[0029] (3) Preparation of antibacterial liquid: add 0.1 part of sodium carboxymethyl cellulose to 100 parts of water for injection while stirring, and stir for 12 hours, then add 2 parts of sorbic acid, 4 parts...

Embodiment 2

[0034] A method for preparing suture thread suitable for biliary tract surgery includes the following steps:

[0035] (1) Preparation of spinning solution: Dissolve chitosan in an acetic acid solution with a mass concentration of 4%, add sodium hyaluronate and polyvinyl alcohol in sequence, stir for 5 hours, then add collagen, continue stirring for 12 hours, and filter , Remove air bubbles under vacuum condition to obtain spinning solution; wherein, the mass ratio of chitosan, acetic acid solution, sodium hyaluronate, polyvinyl alcohol and collagen is 7:97:3:6:4;

[0036] (2) Spinning: The spinning solution is fed into the spinneret with a metering pump, and the spinning solution is squeezed into the coagulation bath while being coagulated and stretched to obtain a thread;

[0037] (3) Preparation of antibacterial liquid: add 0.2 parts of sodium carboxymethyl cellulose to 100 parts of water for injection while stirring, and stir for 24 hours, then add 3 parts of sorbic acid, 6 parts ...

Embodiment 3

[0042] A method for preparing suture thread suitable for biliary tract surgery includes the following steps:

[0043] (1) Preparation of spinning solution: Dissolve chitosan in an acetic acid solution with a mass concentration of 2%, add sodium hyaluronate and polyvinyl alcohol in sequence, stir for 5 hours, then add collagen, continue stirring for 10 hours, and filter , Remove air bubbles under vacuum conditions to obtain spinning solution; wherein, the mass ratio of chitosan, acetic acid solution, sodium hyaluronate, polyvinyl alcohol and collagen is 7:85:3:4:4;

[0044] (2) Spinning: The spinning solution is fed into the spinneret with a metering pump, and the spinning solution is squeezed into the coagulation bath while being coagulated and stretched to obtain a thread;

[0045] (3) Preparation of antibacterial liquid: add 0.1 part of sodium carboxymethyl cellulose to 100 parts of water for injection while stirring, and stir for 24 hours, then add 2 parts of sorbic acid, 6 parts ...

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Abstract

The invention discloses a suture line applicable to an operation of biliary tract and a preparation method thereof. The suture line is prepared by the following methods: (1) preparing a spinning solution, namely dissolving chitosan in acetic acid solution with mass concentration of 2-4%, sequentially adding sodium hyaluronate and polyvinyl alcohol, stirring for 3-5 hours, adding collagens, further stirring 10-12 hours, filtering, and removing bubbles under vacuum conditions, thereby obtaining the spinning solution; (2) spinning, namely infusing the spinning solution into a spinning nozzle by using a metering pump, extruding the spinning solution into a coagulating bath, and stretching while coagulating, thereby obtaining the thread; (3) preparing antibacterial liquid; and (4) dipping and performing after-treatment, namely cleaning the thread obtained in the step (2) by hot water, soaking in the antibacterial liquid obtained in the step (3) for 20-30 minutes, taking out and drying at room temperature, sterilizing and packaging.

Description

Technical field [0001] The invention relates to a surgical suture thread, in particular to a suture thread suitable for biliary tract surgery and a preparation method thereof. It belongs to the field of medical device technology. Background technique [0002] The earliest record of surgical sutures can be traced back to ancient Egypt in 3000 BC, and the oldest known suture is on a mummified body in 1100 BC. The first detailed written record of the suture of wounds and the use of suture materials came from the Indian saint and physician Suxruta in 500 BC. [0003] Surgical suture thread refers to a special thread used for ligation to stop bleeding, suture to stop bleeding, and tissue suture during surgical operations or trauma treatment. In ancient times, catgut was widely used for surgical sutures. With the development of the chemical industry, numerous absorbent and non-absorbent synthetic threads developed rapidly. Nowadays, most sutures are made of polymer fibers. Among the a...

Claims

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Application Information

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IPC IPC(8): A61L17/10A61L17/14A61L17/00
CPCA61L17/005A61L17/10A61L17/145A61L2300/21A61L2300/232A61L2300/30A61L2300/404A61L2300/606
Inventor 王金宝马金海
Owner LINYI YISHUI CENT HOSPITAL
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