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New use of chloroquine

A new use, the technology of chloroquine, applied in the field of medicine

Active Publication Date: 2017-01-04
INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Moreover, there is no report on the use of chloroquine in overactive bladder

Method used

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  • New use of chloroquine
  • New use of chloroquine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1, the efficacy test of chloroquine in the treatment / or alleviating overactive bladder:

[0018] 1) Overactive bladder and model preparation:

[0019] Operation group: 20 C57B female mice (10 weeks old) were anesthetized by intraperitoneal injection with sodium pentobarbital (40 mg / kg), fixed in supine position, and 75% alcohol was used to disinfect the urethra and its surroundings. The abdominal cavity was opened from the midline to expose the bladder and mobilize the urethra. The polyethylene PE50 catheter was inserted into the bladder through the urethra, the urethra was ligated at the bladder neck with 4-0 nylon thread, the tightness was moderate, the catheter was pulled out, the incision was sutured, and the operation was completed to obtain mice in the operation group, i.e. mice with overactive bladder ( OAB mice).

[0020] Sham operation group: 20 C57B female mice (10 weeks old) were subjected to the same operation as above, but no ligation operation...

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PUM

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Abstract

The invention discloses a new use of chloroquine or a pharmaceutically acceptable salt thereof, wherein the new use is a use of chloroquine or the pharmaceutically acceptable salt thereof in preparation of a drug for treating and / or alleviating overactive bladder. The chloroquine can be commercialized chloroquine, the chloroquine pharmaceutically acceptable salt can be a chloroquine pharmaceutically acceptable water-soluble salt, and in addition, the drug with the chloroquine as an active ingredient can also be used for treating and / or alleviating overactive bladder. Experiments find out that the chloroquine can significantly improve abnormal urination caused by urethral obstruction, can significantly delay the abnormal bladder form caused by urethral obstruction and can be used for treating and / or alleviating overactive bladder caused by urethral stricture.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a new application of chloroquine. Background technique [0002] Chloroquine (Chloroquine) is a 4-aminoquinoline drug, English name: Chloroquine, molecular formula: C 18 h 26 ClN 3 , Strength: 319.87, CAS NO: 54-05-7, tablet, each tablet contains 0.075g of chloroquine phosphate. It was first used to treat malaria in 1944, and its use has gradually expanded since then. In 1951, it was used to treat rheumatoid arthritis. [0003] Chloroquine mainly acts on the red inner stage of Plasmodium, which may interfere with the replication and transcription process of Plasmodium schizont DNA or hinder its endocytosis, so that the parasite dies due to lack of amino acids. This product can effectively control the onset of malaria symptoms. It has no effect on the infrared phase and cannot prevent recurrence, but because of its long-lasting effect, it can delay recurrence (fa...

Claims

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Application Information

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IPC IPC(8): A61K31/4706A61P13/10A61P7/12
Inventor 姬广聚翟奎
Owner INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES
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