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Method for identifying quality of traditional Chinese medicine mirabilite based on FT-IR fingerprint method

A fingerprint, mirabilite technology, applied in measuring devices, material analysis through optical means, instruments, etc., can solve the problems of long storage time, inability to identify authenticity, no equipment, etc., to achieve the effect of convenient use

Inactive Publication Date: 2017-01-04
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, compared with the research and quality control of botanical medicines, the quality of mineral medicines on the market is uneven, the origin and batch number are ambiguous, the storage time is long, and it is easy to weather to produce a white powder state. The professional skills and expertise of pharmacy staff Weak, sometimes misleading customers to buy counterfeit products, if only relying on the appearance of white powder to judge, even pharmacy staff and other professionals can not identify the authenticity, there is a certain blind spot in the quality supervision of mineral medicine
[0004] Glauber's salt is a commonly used mineral medicine. Modern research mainly focuses on the pharmacological compound of Glauber's salt, while the analysis mainly focuses on X-ray diffraction and ICP-MS research. The amount of equipment used for the two is not large, and conventional Chinese medicine companies are not equipped. Related instruments and equipment, if equipped, will also cause a certain economic burden

Method used

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  • Method for identifying quality of traditional Chinese medicine mirabilite based on FT-IR fingerprint method
  • Method for identifying quality of traditional Chinese medicine mirabilite based on FT-IR fingerprint method
  • Method for identifying quality of traditional Chinese medicine mirabilite based on FT-IR fingerprint method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The Fourier Transform Infrared Spectrum of Embodiment 1 Glauber's Salt Combined with the Establishment of the Mean Fingerprint Method

[0040] 1. Samples of the sulfate mineral drug Natrii Fulfas were collected from the market and were identified by Professor Li Shuyuan from the School of Chinese Materia Medica of Guangdong Pharmaceutical University. Except for M9 and M13, they were all sulfate mineral drug Natrii Fulfas. See Table 1 for the batch number, place of origin, notes and content of Glauber’s salt medicinal material samples.

[0041] Table 1 The batch number, place of origin, notes and content of samples of mirabilite medicinal material.

[0042]

[0043]

[0044] 2. Take 28 samples of Glauber’s salt from different batches and origins, that is, except M9 and M13 in the table, 10 mg of Glauber’s salt samples from M1 to M30 and 28 parts of 150 mg of dried potassium bromide reagent are mixed and ground in an agate mortar and mortar evenly Grind it finely, ...

Embodiment 2

[0047] Verification of the Fourier Transform Infrared Spectrum Average Fingerprint of Example 2 Glauber's Salt

[0048] 1. The precision, repeatability and stability of Fourier transform infrared spectroscopy detection method

[0049] The precision (n=6) of the samples was done, the RSDs of the common peaks of the precision were all less than 0.23%, and the RSDs of the transmittance were all less than 1.63%; the repeatability experiments (n=6), the RSDs of the common peaks of the repeatability were all less than 1.63%. 0.46%, the RSD of the transmittance is less than 2.89%; the common peak RSD of the repeatability 12h is less than 0.36%, and the RSD of the transmittance is less than 2.72%. It shows that the method is accurate and reliable.

[0050] 2. Fourier Transform Infrared Spectrum Average Fingerprint Similarity Evaluation

[0051] With the help of SPSS.20 software, the average value of the common peak transmittance of the average fingerprint of Glauber's salt samples w...

Embodiment 3

[0054] Example 3 Fourier Transform Infrared Spectrum Combined with Average Fingerprint Analysis and Identification Sample Method

[0055] 1. Actual measurement

[0056] Prepare and measure the sample with band determination according to the preparation method, scan a Fourier transform infrared spectrogram, compare it with the average fingerprint of Glauber's salt, and compare the peak number, wave number, peak position and similarity of the common peaks, so as to identify the Whether the mineral medicine of the sample is Glauber's salt, a sulfate mineral medicine.

[0057] 2. The results are shown in Table 2 and Figure 4 shown.

[0058] Table 2 Similarity Analysis of Glauber's Salt Infrared Fingerprint Spectrum

[0059]

[0060]

[0061] The above results show that the correlation coefficient in the Glauber's salt medicinal material sample is greater than 0.8900, and the cosine value of the included angle is greater than 0.9114. Through the calculation of the mean va...

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Abstract

The invention discloses a method for identifying quality of traditional Chinese medicine mirabilite based on an FT-IR fingerprint method. Mirabilite samples in different batches are collected in the market to conduct infrared spectroscopy scanning to obtain a Fourier transform infrared spectrogram (FT-IR), and an infrared spectroscopy average fingerprint of the mirabilite medicine is established according to the peak position of a common peak and the transmittance. The samples to be detected are put into an infrared spectrometer to be subjected to infrared spectroscopy scanning to detect the Fourier transform infrared spectrogram to be compared with the average fingerprint of the mirabilite, the peak position and the peak number of the common peak are compared to conduct similarity calculation, so as to identify the authenticity of the samples and judge whether the mineral medicine mirabilite meets the requirements of Chinese pharmacopoeia, the good manufacturing practice (GMP), the good supply practice (GSP) and the clinical application or not, the new identifying method is provided for detecting the quality of the mirabilite, and a certain scientific basis is provided for quality supervision of mineral medicines in the market.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine detection. More specifically, it relates to a method for identifying the quality of the traditional Chinese medicine Glauber's salt based on FT-IR fingerprinting. Background technique [0002] Glauber's salt, a traditional Chinese medicine, is a sulfate mineral drug, Glauber's salt. It is processed and refined crystals, mainly containing hydrous sodium sulfate (Na 2 SO 4 10H 2 O), the properties are plate columnar, colorless, transparent and glass-like luster, easy to weather. It has the effects of purging and laxative, moistening dryness and softening hardness, clearing fire and reducing swelling, etc. It is clinically used for stagnation of excess heat, dry stool, mastitis, hemorrhoid swelling and pain. [0003] At present, compared with the research and quality control of botanical medicines, the quality of mineral medicines on the market is uneven, the origin and batch...

Claims

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Application Information

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IPC IPC(8): G01N21/3563
CPCG01N21/3563G01N2021/3595
Inventor 梁生旺闫蔚王淑美
Owner GUANGDONG PHARMA UNIV
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