Application of G protein coupling receptor 18 agonist in preparation of infection drugs

A technology of protein-coupled receptors and coupled receptors, which is applied in the field of medicine, can solve problems that have not been reported in the literature, and achieve obvious effects

Inactive Publication Date: 2017-01-25
安徽济人药业股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In previous studies, there was no literature report on the treatment of infection by G protein-coupled receptor 18 agonists. Most of the previous literatures focused on the effect of G protein-coupled receptor 18 agonists on reducing intraocular pressure (IOP) and neurological diseases. Most of the research

Method used

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  • Application of G protein coupling receptor 18 agonist in preparation of infection drugs
  • Application of G protein coupling receptor 18 agonist in preparation of infection drugs
  • Application of G protein coupling receptor 18 agonist in preparation of infection drugs

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Embodiment Construction

[0034] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further elaborated below in conjunction with specific embodiments, but the following embodiments are only preferred embodiments of the present invention, not all. Based on the examples in the implementation manners, other examples obtained by those skilled in the art without making creative efforts all belong to the protection scope of the present invention.

[0035] Specific embodiments of the present invention will be described below in conjunction with the accompanying drawings.

[0036] The rat model used in the experiment was SPF (Specific pathogen Free) grade SD (Sprague-Dawley) rats, male, 8-10 weeks old, weighing 220-250 g, purchased from the Experimental Animal Center of Fudan University School of Medicine.

[0037] 1. Pathological evidence of the protective effect of G protein-coupled receptor 18 agonist...

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Abstract

The invention provides application of G protein coupling receptor 18 agonist in the preparation of infection drugs; an endotoxin-induced rat is treated with the G protein coupling receptor 18 agonist, lung tissues of the rat are taken on first, third, fifth and seventh days, pathogenic condition of tissue inflammation is observed, it can be seen from pictures that the G protein coupling receptor 18 agonist can significantly inhibit inflammation and immunity symptom reaction of the endotoxin-induced rat, and therefore, the G protein coupling receptor 18 agonist is applicable to the treatment of infection and immunity diseases; the G protein coupling receptor 18 agonist is significantly effective in inhibiting endotoxin-induced lung tissue inflammation reaction and is applicable to the preparation of drugs for treating sepsis infections; scientific evidences are provided for the clinical application of the G protein coupling receptor 18 agonist in treating sepsis infections.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a G protein-coupled receptor 18 agonist in the preparation of a drug for treating infection. Background technique [0002] The respiratory tract, gastrointestinal tract, urinary system and skin of the human body have the physiological characteristics of being in contact with and open to the outside world, and are vulnerable to various viruses, bacterial infections and physical and chemical damage, resulting in infection and immune disorders that seriously endanger human health. One of the diseases, infection and immune dysregulation dominates the causes of infectious death in elderly patients and imposes a huge economic burden on society. Viral and bacterial infectious diseases are currently treated with antibacterial and antiviral treatments and maintaining the stability of the body's internal environment, which is of great significance for the treatment of i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/198A61K31/05A61P31/16A61P31/20A61P31/22A61P31/14A61P31/04A61P31/00A61P37/00A61P17/06A61P17/00A61P37/08
CPCA61K31/05A61K31/198A61K45/00
Inventor 陶振钢袁颖郑武洪朱强朱月信黄超兰薛明明宋振举童朝阳姚晨玲
Owner 安徽济人药业股份有限公司
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