Model for osteoporosis internal fixation by combining BMP-9 gene and Aln

A technology for osteoporosis and BMP-9, which is used in genetic engineering, plant genetic improvement, double-stranded DNA virus, etc.

Inactive Publication Date: 2017-02-15
THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there is no relevant data reported on the effect of BMP-9 gene transfection combined with Aln treatment on the stability of metal bone implants in osteoporosis

Method used

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  • Model for osteoporosis internal fixation by combining BMP-9 gene and Aln
  • Model for osteoporosis internal fixation by combining BMP-9 gene and Aln

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Embodiment Construction

[0021] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0022] The application principle of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0023] Such as figure 1 As shown, the BMP-9 gene of the embodiment of the invention combined with Aln comprises the following steps to the construction method of the model of osteoporosis internal fixation:

[0024] S101: After the rats were weighed, they were anesthetized by intraperitoneal injection of 3.5% chloral hydrate at a rate of 1ml / 100g body weight. Disinfect the operating area and spread sterile drapes;

[0025]S102: Take the proximal 1cm of the longest presacral transver...

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Abstract

The invention discloses a model for osteoporosis internal fixation by combining BMP-9 gene and Aln. 64 six-month-age Sprague-Dawley female rats are prepared, night and day are alternated in 12 hours, ambient temperature is 22 DEG C, the rats take food and drink water freely, rodent standard food is fed, each cage contains 4 rats, adaptive feeding is carried out for 7 days, and then an animal experiment is carried out; after an osteoporosis rat model is made, the rats are divided into a pure screw fixation group, an Aln group, a BMP-9 transfection group, a BMP-9 transfection+Aln group according to completely randomized block design, and each group comprises 16 rats; 8 rats in each group are killed 4 weeks and 8 weeks after screws are implanted respectively, and experimental index detection is carried out. The model disclosed by the invention combines a BMP-9 gene and Aln, bone mass at the periphery of the screws can be obviously improved, pulling-out resisting capability of the screws is improved, and contact rate of bone and the screws is improved; the model disclosed by the invention has an interaction effect in the aspects of increasing mass of bone tissues at the periphery of plants in metal and increasing contact with the bone.

Description

technical field [0001] The invention belongs to the technical field of internal fixation of osteoporosis, and in particular relates to a model of internal fixation of osteoporosis by combining BMP-9 gene with Alendronate Aln. Background technique [0002] In osteoporosis, the bone metabolism of the patient is in a state of high turnover, the biomechanical strength of the bone is reduced, and the bone fragility is increased. When implant internal fixation is required, drilling or implantation of screws or prostheses is likely to cause microfractures and local heat injury, induce early inflammatory reactions around the implant, increase the accumulation of osteoclasts, and cause osteolysis or bone resorption. However, in patients with osteoporosis, the expression of self-repair factors is lacking, and the bone repair effect is reduced, which eventually leads to osteoporosis. The screw loosened, the prosthesis shifted and subsided, and the operation failed. In recent years, re...

Claims

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Application Information

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IPC IPC(8): A61D1/00A61D7/00C12N15/861A01K67/027
CPCA61D1/00A01K67/027A01K2207/12A01K2227/105A01K2267/03A61D7/00C12N15/861C12N2710/10043
Inventor 胡侦明赵军郝杰沈皆亮
Owner THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY
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