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Pharmaceutical composition for promoting bone healing after osteoportic fracture operations and application of pharmaceutical composition

A technology of osteoporosis and composition, which is applied in the field of medicine, can solve the problems of undiscovered combination therapy drugs of statins and ketorolac tromethamine, and achieve the goal of accelerating healing, improving mechanical properties, and reducing toxic and side effects Effect

Inactive Publication Date: 2015-05-06
THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
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AI Technical Summary

Problems solved by technology

[0005] At present, in the treatment of osteoporosis or the healing of osteoporotic fractures at home and abroad, no therapeutic drug with the combination of statins and ketorolac tromethamine as the main active ingredient has been found.

Method used

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  • Pharmaceutical composition for promoting bone healing after osteoportic fracture operations and application of pharmaceutical composition

Examples

Experimental program
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Effect test

Embodiment 1

[0015] Example 1: Effect test of lovastatin combined with ketorolac tromethamine on castrated osteoporotic fracture model

[0016] Select 40 7-month-old clean-grade SD rats, female, with a body weight of 280-320 g, and randomly divide them into a sham operation group, a model control group, a lovastatin group, a ketorolac tromethamine group, and a combined treatment group. Group of 8.

[0017] Except for the sham operation group, the other groups underwent bilateral ovariectomy. The procedure was as follows: the rats were anesthetized by intraperitoneal injection of 10% chloral hydrate at a weight of 2m1 / kg body weight, and a median longitudinal incision was made in the abdominal cavity after skin preparation. 3cm, incision layer by layer, to expose the internal organs of the abdominal cavity, use sterile cotton swabs to find the end of the uterus on both sides, completely remove the bilateral ovarian tissue attached to the end of the uterus, and ligate the stump with silk thr...

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Abstract

The invention discloses a pharmaceutical composition for promoting bone healing after osteoportic fracture operations and application of the pharmaceutical composition. The pharmaceutical composition comprises statins and ketorolac tromethamine, wherein the statins are selected from one or more of simvastatin, lovastatin and atorvastatin. The pharmaceutical composition has the advantages of improving the bone mass of osteoporosis patients to a greater extent and accelerating the healing of osteoportic fracture to improve the mechanical property.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for fracture operation and its application in promoting bone healing after osteoporotic fracture operation and the like. Background technique [0002] Osteoporosis (OP) is a systemic bone metabolic disease characterized by decreased bone mass per unit volume, decreased number of trabecular bone, thinning of cortical bone, destruction of fine structure of bone tissue, widening of bone marrow cavity, and bone loss. It is characterized by increased fragility and increased risk of fracture, and is a common and frequently-occurring disease in clinical practice. Fractures are the most serious consequence of osteoporosis, and fractures heal more slowly than normal. At present, there are more than 200 million osteoporosis patients in the world, and the fractures caused by it account for 33% of women over the age of 50 and 20% of men. Traditiona...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/407A61P19/10A61P19/08A61K31/366A61K31/22A61K31/40
Inventor 杨林曾萍周迎锋张超马超
Owner THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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