Aromatase inhibitor prepared through plant extracts and manufacturing method of aromatase inhibitor

A plant extract and aromatase technology, applied in the field of medicine, can solve the problems of bone density loss, increase the risk of osteoporotic fractures, etc., and achieve the effect of reducing estrogen content

Inactive Publication Date: 2017-03-22
ZHEJIANG FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But they are also often associated with some adverse side effects, such as loss of bone density, bone pain, inhibition of bone formation, increased risk of osteoporosis, fractures, etc.

Method used

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  • Aromatase inhibitor prepared through plant extracts and manufacturing method of aromatase inhibitor

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Embodiment

[0020] The aromatase inhibitor prepared from the plant extract provided in this example, the aromatase inhibitor is formulated as follows in terms of weight percentage: it contains 20-30% of golden buckwheat extract, 40% of Clover extract -45% and Mulberry Leaf Extract 20-40%. Aromatase is a complex enzyme belonging to cytochrome P450, which can oxidize and remove the 19-methyl group of C19 steroids (androstenedione and testosterone), aromatize the A ring, and convert it into C18 estrogen (estrone and estradiol), and this aromatase inhibitor can prefabricate the activity of aromatase, that is, cut off the transformation process, and play an inhibitory role.

[0021] The method for making an aromatase inhibitor includes the following steps: (1) preparing raw materials: selecting golden buckwheat, cloverleaf, and three mulberry leaves as raw materials, crushing the three respectively, and extracting them separately; (2) extracting them with ethanol The method is to obtain golde...

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Abstract

The invention discloses an aromatase inhibitor prepared through plant extracts. The aromatase inhibitor is characterized in that the aromatase inhibitor includes, by weight percent, 20%-30% of wild buckwheat extracts, 40%-50% of radix tetrastigme extracts, 20%-40% of mulberry leaf extracts and an added traditional Chinese medicine composition used for preventing osteoporosis. The manufactured aromatase inhibitor can inhibit conversion from male hormones to female hormones and belongs to the aromatase inhibitor of a non-steroid kind, activity of aromatase is inhibited, the content of the female hormones in the body can be effectively reduced, and the aromatase inhibitor can be used for treating or preventing the breast cancer; and meanwhile, due to the fact that in the formula, the synergistic effect of various kinds of traditional Chinese medicines in the formula is utilized in the traditional Chinese medicine composite formula, the effect of the medicine for treating osteoporosis is sufficiently achieved

Description

technical field [0001] The invention relates to the field of pharmaceutical technology, in particular to an aromatase inhibitor prepared from plant extracts and a preparation method thereof. Background technique [0002] Breast cancer is a common and frequently-occurring disease that seriously affects women's health and even threatens their lives. The treatment of breast cancer currently mainly adopts a comprehensive treatment model of surgery, supplemented by chemotherapy, radiotherapy, endocrine therapy and molecular targeted therapy. Endocrine therapy has developed into an important means of treatment for breast cancer, especially after the discovery of hormone receptors, endocrine therapy for breast cancer can be purposefully selected and the curative effect can be predicted. The advent of aromatase inhibitors has brought endocrine therapy into a new era. [0003] Aromatase exists in the endoplasmic reticulum of cells and is a cytochrome P450 enzyme that converts andro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/70A61K36/9064A61P35/00A61P19/10A61P5/32
CPCA61K36/70A61K36/185A61K36/21A61K36/232A61K36/236A61K36/258A61K36/284A61K36/286A61K36/39A61K36/40A61K36/43A61K36/47A61K36/48A61K36/537A61K36/605A61K36/638A61K36/804A61K36/888A61K36/9064A61K2236/333A61K2236/53A61K2300/00
Inventor 杨胜祥况燚周国泉
Owner ZHEJIANG FORESTRY UNIVERSITY
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