Application of oleum fructus bruceae in preparation of medicines for treating ulcerative colitis

A technology of ulcerative colitis and javanica javanica oil, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., to reduce intestinal inflammatory response, repair pathological changes of the colon tissue, and reduce mucosal damage

Inactive Publication Date: 2017-04-26
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are no reports at home and abroad about the research on the treatment of ulcerative colitis by javanica javanica oil

Method used

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  • Application of oleum fructus bruceae in preparation of medicines for treating ulcerative colitis
  • Application of oleum fructus bruceae in preparation of medicines for treating ulcerative colitis
  • Application of oleum fructus bruceae in preparation of medicines for treating ulcerative colitis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 (preparation and identification of Brucea javanica oil emulsion)

[0019] 1. Brucea javanica oil emulsion whose surface active substance is soybean lecithin

[0020] 1. Prescription: 100g of refined javanica oil, 15g of refined soybean lecithin, and the rest is water.

[0021] 2. Preparation method: Mix refined soy lecithin with appropriate amount of water, transfer it to a high-speed tissue masher (8000 rpm), stir twice, the first time for 5 minutes, and the second time for 2 minutes to make it evenly dispersed , add warm javanica javanica oil, stir 3 times, each 2 minutes, make into colostrum, add water to 1000mL, then transfer to the high-pressure homogenizer (40MPa) and homogenize three times, filter, get the filtrate, Potting, sterilization, that is. The volume content of javanica javanica oil in the gained finished product is 10%.

[0022] 3. Composition analysis of Brucea javanica oil emulsion:

[0023] Agilent 7890B-5977A gas chromatography-mass...

Embodiment 2

[0037] Embodiment 2 (effect experiment)

[0038] 1. Experimental materials

[0039] 1.1. Experimental animals

[0040] SPF grade Balb / C mice, male, 22-24 g, were purchased from Guangdong Medical Experimental Animal Center (certificate number: 44007200030937). The experimental animals were housed in separate cages, the bedding was changed every 2 days, and the adaptive feeding was carried out for 7 days. Water and food were free to drink during the experiment. The temperature of the feeding environment is 22±2°C, the relative humidity is 60%, and the cycle of 12 hours of light and 12 hours of darkness is carried out every day.

[0041] 1.2. Experimental reagents

[0042] Modeling and administration reagents: dextran sodium sulfate (DSS, Lot: Q1723, M.W.36000-50000), MPbiomedicals, LLC; Sulfasalazine (SASP), Shanghai Sanwei Pharmaceutical Co., Ltd.; Azathioprine (AZA), Aspen Group of Companies; Distilled Water, Watsons;

[0043] Reagents for cytokine determination and secti...

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Abstract

The invention relates to an application of oleum fructus bruceae in preparation of medicines for treating ulcerative colitis. The medicine in the application disclosed by the invention is oleum fructus bruceae emulsion, wherein the volume content of the oleum fructus bruceae in the emulsion is 5-20%. The oleum fructus bruceae in the medicine disclosed by the invention can achieve the effects of restoring the colon length, repairing histopathological change, reducing the expression of MPO, COX-2 and iNOS and levels of inflammatory cytokines such as TNF-alpha, IL-1beta, IL-6, IL-8, IL-17 and IFN-gamma in colon tissues, inhibiting activation of proteins such as p65, p-p65, IkB-alpha and p-IkB-alpha in an NF-kB pathway, further down-regulating a complicated proinflammatory cytokine network and alleviating intestinal inflammatory reactions and mucosa injuries.

Description

technical field [0001] The present invention relates to pharmaceutical preparations characterized by special physical shapes, in particular to pharmaceutical preparations containing undetermined structures from Brucea javanica, especially to pharmaceutical preparations containing Brucea javanica oil. Background technique [0002] Ulcerative colitis (Ulcerative Colitis, UC) is a digestive tract disease characterized by chronic inflammation and ulceration. The course of the disease is lengthy and the range of lesions is extensive. Most of the lesions are limited to the mucosal layer and submucosa. The main causes are large areas of congestion, edema, erosion and ulceration of the mucosa. There is no record of the disease name of ulcerative colitis in the historical materials of traditional Chinese medicine, but in terms of symptoms and characteristics, UC belongs to the categories of "dysentery", "intestinal dysentery" and "stagnation" in traditional Chinese medicine. UC has ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/107A61P1/04
CPCA61K9/107A61K36/185A61K47/24
Inventor 苏子仁林志秀黄燕凤赖小平谢友良张晓君
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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