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Application of silver leaf tree fruit in preparing drug for treating ulcerative colitis

A technology for ulcerative colitis and fruit, which can be applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., and can solve the problem of less fruit

Inactive Publication Date: 2020-05-05
GUANGDONG ACAD OF FORESTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research of silver leaf tree mainly focuses on the bark and leaves, but there are very few research reports on the fruit, which may also have the effect of treating dysentery

Method used

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  • Application of silver leaf tree fruit in preparing drug for treating ulcerative colitis
  • Application of silver leaf tree fruit in preparing drug for treating ulcerative colitis
  • Application of silver leaf tree fruit in preparing drug for treating ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 (preparation of the water extract of silver leaf fruit)

[0019] The fruit of the silver leaf tree was collected from Nansha Wetland Park, Nansha District, Guangzhou City, and was identified by the Guangdong Academy of Forestry Sciences.

[0020] The fruit of Silver Leaf Tree was dried at 60°C to constant mass, crushed, and passed through an 80-mesh sieve to obtain a dry powder for later use. Take 100g of silver leaf fruit dry powder, add 2000mL of distilled water to decoct and extract twice, each time for 2h, filter and combine the filtrate obtained twice, evaporate and concentrate to remove most of the water, set the volume to 100mL, and prepare a concentration of The 1g / mL aqueous extract was stored in a refrigerator at 4°C for later use.

Embodiment 2

[0021] Embodiment 2 (effect experiment)

[0022] 1. Experimental materials

[0023] 1.1. Experimental animals

[0024] SPF grade Balb / C mice, 119, male, 6-8 weeks old, body weight 23-25g, provided by the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine, animal certificate number: 44005800006408.

[0025] 1.2. Instruments and equipment

[0026] EL204 analytical balance, Mettler Toledo, Switzerland; H1850R refrigerated high-speed centrifuge, Xiangyi Centrifuge Instrument Co., Ltd.; BX53 optical microscope, Olympus, Japan; HM304E paraffin slicer, ThermoFisher Scientific, USA; IKA10 homogenizer, IKA, Germany; Electric constant temperature incubator, Shanghai Jinghong Experimental Equipment Co., Ltd.; Multiskan Go1510 full-wavelength microplate reader, 5020 gradient PCR instrument, NanoDrop2000C ultra-micro spectrophotometer, Thermo Fisher Scientific, USA; CFX96 real-time fluorescence quantitative PCR, Bio-rad, USA ; EPS300 vertical electrophore...

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PUM

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Abstract

The invention relates to application of silver leaf tree fruit in preparing a drug for treating ulcerative colitis. In the application, the drug can restore the length of a colon, repair pathologicalchanges in colon tissues, lower the MPO activity in the colon tissues, and down-regulate expression of COX-2, iNOS, IL-12 and IL-17 as well as levels of inflammatory cytokines TNF-alpha, IFN-gamma, IL-6 and IL-1 beta, inhibit expression of proteins p-65, p-p65P, p-IKK alpha and P-I kappa B alpha in an NF-kappa B pathway, promote expression of IKK alpha and I kappa B alpha and thus further down-regulate complex a pro-inflammatory cytokine network reduce intestinal inflammatory response and mucosal injury.

Description

[0001] field of invention [0002] The invention relates to a medical preparation, in particular to a medicine containing an undetermined structure from the fruit of the Argyra plant, which is suitable for treating ulcerative colitis. Background technique [0003] Ulcerative colitis (Ulcerative Colitis, UC) is a digestive tract disease characterized by chronic inflammation and ulceration. The course of the disease is long and the lesion range is extensive. The lesion originates from the rectum, but is limited to the colon. It is more common in the intestinal mucosa and lower layer, and some accumulate in the terminal ileum. The main pathological features are intestinal mucosal erosion, continuous congestion and swelling, and shallow small ulcers Mainly. There is no record of the disease name of ulcerative colitis in the historical materials of traditional Chinese medicine, but in terms of symptoms and characteristics, UC belongs to the categories of "dysentery", "enteric dyse...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/04A61K131/00
CPCA61K36/185A61K2236/331A61K2236/39A61P1/04
Inventor 蔡坚张谦高常军林国盛刘晶晶苏子仁
Owner GUANGDONG ACAD OF FORESTRY