Preparation of metronidazole slow-release drug membrane for teeth

A technology of metronidazole teeth and metronidazole, which is applied in the production field of metronidazole dental slow-release drug film, can solve the problems of poor medical effect, large side effects, and large dosage of medicine, and achieve slow test effect and high drug concentration. High, long-lasting effect

Inactive Publication Date: 2017-05-03
于明梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the problems of oral tablet metronidazole for the treatment of periodontal disease, the dosage of medicine is large, the medical effect is poor, and the side effects are large, a kind of absorbable metronidazole drug film with polymer material as the slow-release carrier is invented

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1 10.71 grams of metronidazole, 28.58 grams of sodium carboxymethylcellulose, 42.85 grams of polyvinyl alcohol-124, and 17.86 grams of starch. First soak 42.85 grams of polyvinyl alcohol-124 and 28.58 grams of sodium carboxymethyl cellulose for 10 hours to dissolve respectively, and grind 10.71 grams of metronidazole and 17.86 grams of starch with water, then mix the above-mentioned 42.85 grams of polyvinyl alcohol-124, 28.58 gram carboxymethylcellulose sodium, 10.71 gram metronidazole, and 17.86 gram starch gelatinous liquid are mixed and stirred evenly; then add preservatives and sodium saccharin, dilute with distilled water to form an easy-to-apply paste, and spread it on a flat board. Thin layer, dry naturally to form a film.

Embodiment 2

[0011] Example 2, Take 21.42 grams of metronidazole, 57.16 grams of sodium carboxymethylcellulose, 85.70 grams of polyvinyl alcohol-124, and 35.72 grams of starch. First soak 85.70 grams of polyvinyl alcohol-124 and 57.16 grams of sodium carboxymethyl cellulose for 14 hours to dissolve, and grind 21.42 grams of metronidazole and 35.72 grams of starch with water, then mix the above-mentioned 85.70 grams of polyvinyl alcohol-124, 57.16 gram carboxymethyl cellulose sodium, 21.42 gram metronidazole, 35.72 gram starch colloidal solution, mix and stir evenly; then add preservatives, saccharin sodium, dilute with distilled water and reconcile into a paste that is easy to smear, spread out on a flat board Thin layer, dry naturally to form a film.

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PUM

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Abstract

Preparation of a metronidazole slow-release drug membrane for teeth is characterized in that the membrane comprises a metronidazole standard substance, sodium carboxymethylcellulose and polyvinyl alcohol-124. The membrane is made from, according to a ratio, 10.71% of metronidazole, 28.58% of sodium carboxymethylcellulose, 42.85% of polyvinyl alcohol-124, and 17.86% of starch. The problem that an orally-administered metronidazole tablet for treating periodontosis is large in consumption, poor in medical effect and large in side effect is solved. The membrane is widely suitable for patients who suffer from periodontosis.

Description

technical field [0001] The invention relates to the field of preparations of medical drugs, in particular to a preparation method of a metronidazole dental slow-release film. Background technique [0002] At present, in drug treatment of periodontal disease, it is mainly completed by taking metronidazole tablet orally. Its disadvantages are that the dosage of the drug is large, the concentration of the drug in the local periodontal area is low, the medical effect is poor, and it is highly irritating to the gastrointestinal tract. Contents of the invention [0003] In order to solve the problems of large dosage, poor medical effect and large side effects of oral metronidazole in the treatment of periodontal disease, the present invention invents an absorbable metronidazole drug film using polymer material as a slow-release carrier. [0004] The technical solution of the present invention is a preparation of a metronidazole dental slow-release drug film, the composition of w...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/4164A61K47/38A61K47/32A61P1/02A61P31/04
Inventor 于明梅
Owner 于明梅
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