Application of benserazide hydrochloride in preparing medicine for treating acute inflammation

A technology for benserazide hydrochloride and acute inflammation, which is applied in the field of biomedicine and can solve the problems such as no benserazide hydrochloride treatment of acute inflammation yet.

Active Publication Date: 2017-05-31
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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Method used

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  • Application of benserazide hydrochloride in preparing medicine for treating acute inflammation
  • Application of benserazide hydrochloride in preparing medicine for treating acute inflammation
  • Application of benserazide hydrochloride in preparing medicine for treating acute inflammation

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Experimental program
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Embodiment

[0016] Establishment of acute inflammation animal model and drug treatment

[0017] All mice were housed in SPF-grade animal rooms, and fed and watered ad libitum. Fifty C57BL / 6 mice (purchased from the Institute of Model Biology, Nanjing University) were randomly divided into five groups, 10 in each group, respectively blank control group, model control group, benserazide hydrochloride low-dose group (25mg / kg / d), benserazide hydrochloride medium dose group (50mg / kg / d), benserazide hydrochloride high dose group (100mg / kg / d).

[0018] After adaptively feeding the above five groups of mice with basal feed for 1 week, the mice in the low-dose benserazide hydrochloride group were injected with benserazide hydrochloride 25 mg / kg / d, and the mice in the middle-dose benserazide hydrochloride group were injected with benserazide hydrochloride The mice in the 50mg / kg / d and high-dose benserazide hydrochloride groups were injected with 100mg / kg / d of benserazide hydrochloride, while the ...

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Abstract

The invention relates to application of benserazide hydrochloride in preparing medicine for treating acute inflammation and belongs to the technical field of biological medicine. According to the application of benserazide hydrochloride in preparing medicine for treating acute inflammation, a treating effect of the benserazide hydrochloride on acute inflammation is researched through animal experiments, and experiment results show that the benserazide hydrochloride has an inhibiting effect on inflammatory factors generated by mouse acute inflammation caused by lipopolysaccharide. Specifically, a C57BL/6 mouse acute inflammation model is induced to be constructed through the lipopolysaccharide, different concentrations of benserazide hydrochloride is utilized to treat the mouse, results show that the benserazide hydrochloride can reduce inflammatory factor level generated by C57BL/6 mouse acute inflammation and pathological change degree of hepatic tissues, and the low dosage benserazide hydrochloride has the optimal effect. The benserazide hydrochloride is prepared into varieties of preparation required by clinic by adding carriers accepted by pharmacy, and the application of benserazide hydrochloride in preparing medicine for treating acute inflammation has the beneficial effect of providing a novel path for preparing acute inflammation medicine.

Description

technical field [0001] The invention relates to the application of benserazide hydrochloride in the preparation of medicines for treating acute inflammation, and belongs to the technical field of biomedicine. Background technique [0002] Inflammation is a physiological response of vascularized tissue following local injury. During this process, various soluble mediators and inflammatory cells work together in the form of a system to eliminate the factors that cause damage to the body, manifested as redness, swelling, heat, pain and dysfunction. Studies have shown that the inflammatory process is involved in the pathogenesis of many diseases, such as human infection, tumor, cardiovascular and cerebrovascular diseases, senile dementia, neurodegenerative diseases, and allergic diseases. Clinically, anti-inflammatory drugs are the second largest class of drugs next to anti-infective drugs. Serum amyloid P component (SAP) belongs to the pentameric plasma protein family and is ...

Claims

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Application Information

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IPC IPC(8): A61K31/165A61P29/00
Inventor 何书英季璇馨王绍达黄青林
Owner CHINA PHARM UNIV
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