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Antibacterial composition

A composition and silver compound technology, applied in the field of medicine, can solve problems such as lack of clear research results, and achieve the effect of reducing the amount of viable bacteria in the body, reducing the occurrence of drug resistance, and having a good antibacterial effect

Inactive Publication Date: 2017-05-31
SHANGHAI LAIYI BIOMEDICAL RES & DEV CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As for which antibiotics silver can be used in combination with, the dosage range of the combined use, and which microorganisms have a relatively good killing effect, there are no clear research results so far.

Method used

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Examples

Experimental program
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Embodiment 2

[0037] Embodiment 2 and embodiment 9 all adopt Acinetobacter baumannii (Huashan Hospital aba1604) with resistance to carbapenem antibiotics as test bacteria; silver nano.

Embodiment 1

[0038] The synthesis of embodiment 1 silver nano

[0039] Synthesis of Ag-PVP: Add 0.78g of PVP and 49mL of absolute ethanol into a three-neck round bottom flask, mix thoroughly with ultrasound, place in an oil bath at 70°C, and stir the solution with a magnetic stirrer at the same time, slowly add 1 mL of 1% AgNO 3 Solution, keep heating at 70°C for 120min. After the reaction solution was cooled to room temperature, the color of the sol was orange-yellow. TEM detection, figure 1 The TEM image of silver nanometers prepared by this method, figure 2 It is the size distribution of silver nanoparticles, with an average particle size of 13nm.

[0040] Ag-cit synthesis: Add 20mL of 1% trisodium citrate solution and 75mL of water into a three-neck round bottom flask, place it in an oil bath at 70°C, and at the same time, stir the solution with a magnetic stirrer, add 1.7mL of 1% after 15min AgNO 3 solution, then quickly add 2 mL of freshly prepared 0.1% NaBH 4 solution. The ...

Embodiment 3

[0059] Example 3 Preparation of Injection

[0060] formula:

[0061] Silver nitrate 52g, polymyxin B 12.5g, glycine 1.5g, mannitol 3.5g, PVP 1.5g, 1000 tubes were prepared in total.

[0062] Add silver nitrate, polymyxin B, glycine, mannitol, and PVP into 8000ml water for injection, add water for injection to 10000ml, add activated carbon, stir, filter, sterilize, and fill.

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Abstract

The invention discloses an antibacterial composition mainly including an antibiotic and silver as main components, wherein the antibiotic is polymyxin B and the silver includes a silver compound and nano silver. The antibacterial composition, which is prepared from the silver compound or the nano silver and the antibiotic, has antibacterial effect on Acinetobacter baumannii (Ab). The silver compound or the nano silver is combined with the antibiotic, so that the composition has synergistic effect on the Acinetobacter baumannii. Single drug dosage of each of the antibiotic, the silver compound or the nano silver on the Acinetobacter baumannii is reduced, thereby reducing toxic and side effects and reducing drug resistance.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a bacteriostatic composition. Background technique [0002] Since its discovery, antibiotics have played a very important role in human medicine, saving countless lives and contributing to human health. However, due to the widespread use and abuse of antibiotics, the resistance of microorganisms to antibiotics is becoming stronger and stronger, which significantly reduces the anti-infection ability of many antibiotics against microorganisms, and long-term use of antibiotics also has certain toxic side effects on the human body. Therefore, new and more effective antibacterial agents must be found. [0003] Silver is a silver-white metal that has broad-spectrum antibacterial properties against Gram-positive and negative bacteria and fungi, and has the ability to prevent bacterial adhesion. German obstetrician Crede instilled 1% silver nitrate solution into the eyes o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/12A61P31/04A61K33/38
CPCA61K9/0019A61K9/08A61K33/38A61K38/12A61K2300/00
Inventor 万国庆阮林高殷瑜靳旭夏兴罗敏玉戈梅
Owner SHANGHAI LAIYI BIOMEDICAL RES & DEV CENT
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