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A kind of antihypertensive oral tablet and preparation method thereof

An oral tablet, anti-hypertensive technology, applied in the field of medicine, can solve the problems of less than 50% blood pressure compliance rate, combined drug use, etc., and achieve the effects of reducing single drug dosage, simplifying treatment, and increasing production costs

Active Publication Date: 2017-01-18
GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The antihypertensive drugs currently used clinically alone may achieve less than 50% of the antihypertensive target rate, and most patients need to use combination drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The antihypertensive oral tablet is a double-layer tablet, which includes a telmisartan layer and an amlodipine besylate layer; wherein,

[0038]The telmisartan layer is made of the raw materials of the following weight components: Telmisartan 40, sorbitol 17, meglumine 16.5, microcrystalline cellulose 55, pregelatinized starch 55, sodium hydroxide 5, stearic acid Magnesium 1, sodium carboxymethyl starch 4, polyvinylpyrrolidone 6, water 10 and ethanol 10.

[0039] The amlodipine besylate layer is made of the raw materials of the following weight components: amlodipine besylate 5, micropowder silica gel 6, polyvinylpyrrolidone 6, sorbitol 68, cornstarch 62, microcrystalline cellulose 102, pregelatin Starch 78, magnesium stearate 1, sodium carboxymethyl starch 4, ethanol 90, hypromellose 3, black iron oxide 0.315 and yellow iron oxide 0.002.

[0040] Using the above-mentioned raw material components, the method for preparing the antihypertensive oral tablet comprises the...

Embodiment 2

[0050] The antihypertensive oral tablet is a double-layer tablet, which includes a telmisartan layer and an amlodipine besylate layer; wherein,

[0051] The telmisartan layer is made of the raw materials of the following weight components: Telmisartan 40, sorbitol 22, meglumine 12, microcrystalline cellulose 60, pregelatinized starch 60, sodium hydroxide 5, stearic acid Magnesium 1, sodium carboxymethyl starch 4, polyvinylpyrrolidone 6, water 10 and ethanol 10.

[0052] The amlodipine besylate layer is made of the raw materials of the following weight components: amlodipine besylate 5, micropowder silica gel 10, polyvinylpyrrolidone 6, sorbitol 71, cornstarch 55, microcrystalline cellulose 98, pregelatin Starch 78, magnesium stearate 1, sodium carboxymethyl starch 4, ethanol 90, hypromellose 3, black iron oxide 0.315 and yellow iron oxide 0.002.

[0053] Using the above-mentioned raw material components, the method for preparing the antihypertensive oral tablet comprises the ...

Embodiment 3

[0063] The antihypertensive oral tablet is a double-layer tablet, which includes a telmisartan layer and an amlodipine besylate layer; wherein,

[0064] The telmisartan layer is made of the raw materials of the following weight components: telmisartan 40, sorbitol 22, meglumine 16.5, microcrystalline cellulose 50, pregelatinized starch 50, sodium hydroxide 5, stearic acid Magnesium 1, sodium carboxymethyl starch 4, polyvinylpyrrolidone 6, water 10 and ethanol 10.

[0065] The amlodipine besylate layer is made of the raw materials of the following weight components: amlodipine besylate 5, micropowder silica gel 9, polyvinylpyrrolidone 6, sorbitol 93, cornstarch 60, microcrystalline cellulose 37, pregelatin Starch 33, magnesium stearate 1, sodium carboxymethyl starch 4, ethanol 90, hypromellose 3, black iron oxide 0.315 and yellow iron oxide 0.002.

[0066] Using the above-mentioned raw material components, the method for preparing the antihypertensive oral tablet comprises the...

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PUM

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Abstract

The invention discloses an oral tablet for resisting high blood pressure and a preparation method of the oral tablet. The oral tablet is a double-layer tablet and comprises a telmisartan layer and an amlodipine besylate layer, wherein the telmisartan layer is prepared from the following raw materials in parts by weight: 40 parts of telmisartan, 17-30 parts of sorbitol, 12-23 parts of meglumine, 50-68 parts of microcrystalline cellulose, 50-68 parts of pregelatinized starch, 5 parts of sodium hydroxide, 1 part of magnesium stearate, 4 parts of carboxymethyl starch sodium, 6 parts of polyvinylpyrrolidone, 10 parts of water and 10 parts of ethyl alcohol; the amlodipine besylate layer is prepared from the following raw materials in parts by weight: 5 parts of amlodipine besylate, 3-10 parts of aerosol, 6 parts of polyvinylpyrrolidone, 35-93 parts of sorbitol, 55-98 parts of corn starch, 37-102 parts of microcrystalline cellulose, 33-78 parts of pregelatinized starch, 1 part of magnesium stearate, 4-8 parts of carboxymethyl starch sodium, 90 parts of ethyl alcohol, 3 parts of hydroxypropyl methylcellulose, 0.315 part of black iron oxide and 0.002 part of yellow ferric oxide.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the research on preparing antihypertensive oral tablets by using telmisartan and amlodipine besylate. Background technique [0002] Hypertension is one of the common cardiovascular diseases that seriously endanger human health, and it is also a major public health problem worldwide. In the past 50 years, the prevalence of hypertension in my country has also been showing a clear upward trend. According to the survey data of the report on the nutrition and health status of Chinese residents in 2005, the prevalence of hypertension in adults in my country is 8.8%, and the estimated number of patients in the country is Compared with 1991, the prevalence rate has increased by 31%. According to the 2012 China Cardiovascular Disease Report, the prevalence of hypertension in my country is 11.8%, and there are about 150 million hypertensive patients. The awareness rate of hypertension was 33.2%, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4422A61K9/24A61P9/12A61K31/4184
Inventor 赵素枝刘凤鸣于会玲
Owner GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS
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