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Application of new lingxian glycosides in the preparation of medicines for treating or preventing inflammatory bowel disease

A new Lingxian glycoside and Lingxian technology, applied in the field of natural medicine, can solve the problems of excessive distribution of intestinal mucosa, low bioavailability, and undeveloped anti-inflammatory bowel disease

Active Publication Date: 2020-01-31
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its oral bioavailability is low, and it is more distributed in the intestinal mucosa after oral administration. At present, its anti-inflammatory bowel disease effect has not yet been developed.

Method used

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  • Application of new lingxian glycosides in the preparation of medicines for treating or preventing inflammatory bowel disease
  • Application of new lingxian glycosides in the preparation of medicines for treating or preventing inflammatory bowel disease
  • Application of new lingxian glycosides in the preparation of medicines for treating or preventing inflammatory bowel disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The drug efficacy test proved the preventive effect of Lingxianxin glycosides on the Crohn's model of inflammatory bowel disease in rats:

[0025] 1.1 Test method:

[0026] (1) Animal grouping: 48 male SD rats of SPF grade were randomly divided into 6 groups according to body weight, which were set as normal control group (Normal control group, NC group), Crohn's disease model group (Model group, MC group). group), Lingxianxin low dose group (Low dose AR group, AR-L group, 16mg·kg -1 ), Lingxianxin glycosides group (Moddel dose AR group, AR-M group, 32mg·kg -1 ), Lingxianxin high dose group (High dose AR group, AR-H group, 64mg·kg -1 ) and positive drug group (mesalamine, 5-Aminosalicylic acid group, AC group, 500mg·kg -1 ).

[0027] (2) Model establishment: refer to the internationally recognized Morris method, and use the TNBS / ethanol method to construct the model. The rats are first adaptively fed for 1 week, fasted for 24 hours before modeling, weighed, and inje...

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Abstract

The invention discloses application of clematichinenoside AR in preparation of medicine for treating or preventing inflammatory bowel diseases. A medicinal effect test shows that clematichinenoside AR has an outstanding effect of resisting the inflammatory bowel crohn diseases in rats, and can be used for developing a type of novel traditional Chinese medicines which are capable of resisting the inflammatory bowel diseases (including immune inflammatory bowel diseases and inflammatory bowel diseases caused by other reasons) and are high in treating effect and high in safety.

Description

technical field [0001] The invention belongs to the technical field of natural medicines, and in particular relates to the application of a new lingxian glycoside in the preparation of medicines for treating or preventing inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease, referred to as IBD, is a special chronic intestinal inflammatory disease, mainly including Crohn's disease (CD) and ulcerative colitis (UC). Clinically, patients with inflammatory bowel disease manifest as repeated abdominal pain, diarrhea, mucus and bloody stools, and even various systemic complications such as blurred vision, joint pain, and rashes. The disease can be improved after treatment, and can also be relieved by itself. However, most patients relapse and do not heal, and a considerable number of patients require surgical treatment due to complications. [0003] Lingxianxinglucoside is a safe, efficient and stable new natural drug that integrates anti-inflammat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61P1/00
CPCA61K31/715
Inventor 李运曼方伟蓉胡雅慧李丰文刘丽芳朱兴祥
Owner CHINA PHARM UNIV