Applications of Bacteroides in treatment and prevention of obesity-related diseases

A technology of Bacteroides and Bacteroides saccharosa, applied in the field of microbiology, can solve problems such as immune resistance, local or systemic drug allergy, and small side effects

Inactive Publication Date: 2017-06-16
SHENZHEN HUADA GENE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For patients, the use of exogenous insulin is an expensive and painful method, and it also brings many complications to the patient
Insulin response (hypoglycemia) due to miscalculation of insulin doses, for example, due to missing meals or erratic exercis...

Method used

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  • Applications of Bacteroides in treatment and prevention of obesity-related diseases
  • Applications of Bacteroides in treatment and prevention of obesity-related diseases
  • Applications of Bacteroides in treatment and prevention of obesity-related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0118] Example 1 The ratio of raw materials of the food composition containing Bacteroides multiteri, Bacteroides ovale, Bacteroides xylanolyticum or their combination is shown in Table 1.

[0119] Table 1 food composition formula

[0120] raw material Mass percentage (%) Bacterial component 0.5 milk 90.0 white sugar 9.5

[0121] The bacterial components in formulas 1-9 are single bacterial components, containing Bacteroides dorei DSM17855, Bacteroides dorei JCM 13472, Bacteroides dorei BD1, Bacteroides ovatusATCC 8483, Bacteroides ovatus SD CMC 3f, Bacteroides ovatus RF Cell 1b2, xylanisolvens XB1A (DSM 18836), Bacteroides xylanisolvens XB4A, Bacteroides xylanisolvens XB3A.

[0122] The bacteria component in formula 10 is a mixture of any two or more (preferably three) of the above nine bacteria (weight ratio is 1:1 or 1:1:1).

[0123] Mix milk and sugar according to the above formula ratio, stir until completely mixed, preheat, homogenize ...

Embodiment 2

[0125] Pharmaceutical composition containing Bacteroides multierii, Bacteroides ovale, Bacteroides xylanolyticum or combination thereof

[0126] The ratio of raw materials is shown in Table 2.

[0127] Table 2 Pharmaceutical composition formula

[0128] raw material Mass percentage (%) Bacterial component 1.0％ lactose 2.0％ yeast 2.0％ Peptone 1.0％ pure water 94.0％

[0129]The bacterial components in formulas 1-9 are single bacterial components, containing Bacteroides dorei DSM17855, Bacteroides dorei JCM 13472, Bacteroides dorei BD1, Bacteroides ovatusATCC 8483, Bacteroides ovatus SD CMC 3f, Bacteroides ovatus RF Cell 1b2, xylanisolvens XB1A (DSM 18836), Bacteroides xylanisolvens XB4A, Bacteroides xylanisolvens XB3A.

[0130] The bacteria component in formula 10 is a mixture of any two or more (preferably three) of the above nine bacteria (weight ratio is 1:1 or 1:1:1).

[0131] Mix lactose, yeast powder, and peptone evenly with ...

Embodiment 3

[0132] Embodiment 3 for the therapeutic effect of obese model mice

[0133] Experimental Materials:

[0134] Mice: C57BL / 6J male mice (purchased from Guangdong Provincial Medical Experimental Animal Center) were purchased, which were normally bred mice and were 6 weeks old. Mice were raised in the same environment and fed the same food.

[0135] The inventor obtained 9 strains of Bacteroides from the depository institution and preserved them in Shenzhen Huada Gene Research Institute. At the same time, Lactobacillus plantarum (Lactobacillus plantarum) was selected from the General Microbiology Center (CGMCC) of the China Committee for Culture Collection of Microbial Cultures (CGMCC), with the preservation number CGMCC No.8198, as the control group (LP group).

[0136] Among them, the source information of the above nine strains of Bacteroides is shown in Table 3. All strains were identified by 16S rDNA sequencing and the experiment was started.

[0137] See Table 3 for stra...

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Abstract

The present invention discloses applications of Bacteroides in treatment and prevention of obesity-related diseases, particularly applications of Bacteroides in preparation of a composition or preparation, wherein the composition or preparation is used for one or a variety of uses such as (A) prevention and/or treatment of obesity; (b) lowering of blood fat; (c) prevention or treatment of cardiovascular diseases; and/or (d) prevention and/or treatment of diabetes. The Bacteroides of the present invention can significantly reduce the body weight, the blood fat, and the body fat rate.

Description

technical field [0001] The invention belongs to the field of microbiology. Specifically, the invention relates to the application of Bacteroides in the treatment and prevention of obesity and related diseases, and also relates to a composition containing Bacteroides and its application. Background technique [0002] There are a large number of symbiotic microorganisms in the human body, most of which live in the human intestinal tract, and the number exceeds 1000 trillion (10 14 Order of magnitude), more than 10 times the total number of human cells. During the long evolutionary process, intestinal microbes have reached a good cooperation with human beings, and play a vital role in the nutrition, metabolism and immunity of the human body. Many researchers regard the human intestinal microbiome as more It is an "organ" of the human body, or the second genome of the human body, and the massive genetic information contained in it is closely related to human health. Through th...

Claims

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Application Information

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IPC IPC(8): A61K35/741A61P3/10A61P3/04A61P9/00A61P3/06A23L33/135A23K20/10
CPCA23V2002/00A61K35/741A23V2200/332A23V2200/328A23V2200/3262A23V2200/326
Inventor 冯强张东亚
Owner SHENZHEN HUADA GENE INST
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