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Tumor-targeted multi-purpose nanometer drug delivery system as well as preparation method and applications thereof

A nano-drug delivery system, a technology of a drug delivery system, applied in the field of pharmaceutical preparations, can solve problems such as poor curative effect and lack of tracer in the drug delivery system

Active Publication Date: 2017-06-23
EAST CHINA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a tumor-targeted multifunctional nano-drug delivery system modified by the tumor-penetrating peptide RGERPPR, aiming at the problems of lack of tracer in vivo and poor curative effect of the drug delivery system. 3 o 4 / SiO 2 / mSiO 2 / DOX-(Gd-DTPA)-PEG-RGE for the integration of diagnosis and treatment of tumors

Method used

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  • Tumor-targeted multi-purpose nanometer drug delivery system as well as preparation method and applications thereof
  • Tumor-targeted multi-purpose nanometer drug delivery system as well as preparation method and applications thereof
  • Tumor-targeted multi-purpose nanometer drug delivery system as well as preparation method and applications thereof

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Experimental program
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Effect test

Embodiment 1

[0046] Preparation of Fe 3 o 4 Nanoparticles

[0047] After 2.78g of iron oleate was left to stand in a vacuum oven at 30°C for 24 hours, 0.48mL of octadecene was added. The mixture is heated at a rate of 3.3°C min -1 Heated to 320°C and then kept at this temperature for 60 minutes. After the reaction, cool to room temperature, wash with 10mL n-hexane and 40mL acetone, and centrifuge to obtain Fe 3 o 4 Nanoparticles.

Embodiment 2

[0049] Preparation of Fe 3 o 4 / SiO 2 Nanoparticles

[0050] 6.8mg Fe 3 o 4 Nanoparticles and 8 mL of Igepal CO-520 were dissolved in 170 mL of cyclohexane and supernaturated for 30 minutes. Then, 1.3 mL of ammonia water was added dropwise to obtain a transparent inverse microemulsion. Add 1.5mLTEOS dropwise and react at room temperature at 600 rpm for 72 hours. Add acetone to break the emulsion, centrifuge, wash with methanol, and collect Fe 3 o 4 / SiO 2 Nanoparticles.

Embodiment 3

[0052] Preparation of Fe 3 o 4 / SiO 2 / mSiO 2 Nanoparticles

[0053] 2g CTAC and Fe 3 o 4 / SiO 2 Nanoparticles were dissolved in 20mL of water and supergenerated for 30 minutes. Then, 82 μLTEA was added and reacted at 80° C. for 60 minutes. Then add 1.5 mL TEOS and react at room temperature at 600 rpm for 60 minutes. Add acetone to break the emulsion, centrifuge and wash with methanol. Then use 1% NaCl methanol solution, reflux at 60°C for 3 hours, centrifuge, repeat 5 times, remove CTAC, and collect Fe 3 o 4 / SiO 2 / mSiO 2 Nanoparticles.

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Abstract

The invention discloses a tumor-targeted multi-purpose nanometer drug delivery system as well as a preparation method and applications of the tumor-targeted multi-purpose nanometer drug delivery system. The system comprises multi-purpose nanoparticles modified by tumor penetrating peptide RGERPPR and an anti-tumor medicine, wherein the multi-purpose nanoparticles adopt the T1-T2 dual-mode magnetic resonance contrast agent; the anti-tumor medicine is adriamycin or pharmorubicin; and the weight of the anti-tumor medicine accounts for 10-35 % in the system. The drug delivery system has the following features: the grain diameter is 60-200 nm, and the particles are spherical; the T1 contrast agent Gd-DTPA and the T2 contrast agent Fe3O4 are simultaneously utilized, and the highly accurate diagnosis information is provided; the water solubility and biocompatibility of the medicine are improved, and the curative effects and bioavailability of the medicine are improved; the drug delivery system can be used for intravenous injection, and targets to the tumor tissue by utilizing the RGERPPR mediation effect and the tumor EPR effect, and the system has the obvious inhibiting effect for the growth of the brain glioma tumor; and the drug delivery system can be used for realizing the tumor diagnosis and treatment integration.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a targeted nano drug delivery system modified by a polypeptide, in particular to an active targeting multifunctional nano drug delivery system modified by a tumor penetrating peptide RGERPPR, a preparation method and an application thereof. Background technique [0002] Cancer is a major public health problem facing most countries in the world and is the second leading cause of death globally. Currently, chemotherapy is still one of the most effective ways to treat cancer in clinic. However, since conventional chemotherapy drugs cannot be tracked in real time in vivo, their distribution in tumor tissue cannot be known, so it is impossible to provide timely feedback for the clinical effectiveness of drugs. This is also the main reason why tumor chemotherapy cannot achieve individualized treatment. Many scientists believe that it is the main problem faced by traditional ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/64A61K31/704A61K9/51A61P35/00A61K49/08A61K49/10A61K49/18
CPCA61K9/5169A61K31/704A61K49/08A61K49/105A61K49/1866
Inventor 王依婷高礼鹏余静刘秧周靖娥孙磊闫志强王镜朱建中俞磊
Owner EAST CHINA NORMAL UNIV
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