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Preparation method of antioxidant nano emulsion containing vitamins C and E

A nano-emulsion and vitamin technology, which is applied in the direction of medical preparations containing active ingredients, emulsion delivery, cosmetic preparations, etc., can solve the problems that the research on anti-oxidation properties has not been reported, and achieve good synergistic anti-oxidation and good development Effects of foreground and use

Inactive Publication Date: 2017-07-14
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on the antioxidant properties of VC and VE in the nanoemulsion system has not been reported yet.

Method used

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  • Preparation method of antioxidant nano emulsion containing vitamins C and E
  • Preparation method of antioxidant nano emulsion containing vitamins C and E
  • Preparation method of antioxidant nano emulsion containing vitamins C and E

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Experimental program
Comparison scheme
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Embodiment Construction

[0015] 1. Preparation process:

[0016] 1. Preparation method and formula of liquid paraffin containing VE:

[0017] Preparation method: Dissolve a certain amount of VE in liquid paraffin to ensure that the concentration of VE in liquid paraffin is 0.1mmol / L-0.8mmol / L.

[0018] For example: Assuming that the total mass is 5g, and the total mass of surfactant and oil phase (liquid paraffin + VE) accounts for 5% to 15% of the total mass of raw materials for production, the total mass of surfactant and oil phase (liquid paraffin + VE) The mass is 0.25g to 0.75g, and the mass ratio of surfactant to oil phase (liquid paraffin + VE) is between 3:7 and 7:3.

[0019] Here is just an example for a simple calculation description:

[0020] The total mass of surfactant and oil phase (liquid paraffin + VE) accounts for 5% of the total mass of raw materials for production, and the mass ratio of surfactant and oil phase (liquid paraffin + VE) is 3:7.

[0021] Then, the total mass of the s...

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Abstract

The invention relates to a preparation method of an antioxidant nano emulsion containing vitamins C and E and belongs to the technical field of nano emulsions. The preparation method comprises the following steps: firstly, mixing a polyoxyethylene non-ionic surfactant with an oil phase; after magnetic stirring, dropwise adding a vitamin C aqueous solution; and after dropwise addition, continuously stirring the solution to obtain the antioxidant nano emulsion containing vitamins C and E. The antioxidant nano emulsion containing vitamins C and E provided by the invention has good synergic inoxidizability, and the used vitamins C and E and liquid paraffin can be applied to the field of medicines and cosmetics.

Description

technical field [0001] The invention belongs to the technical field of preparation of nanoemulsions. Background technique [0002] Nanoemulsion is also called microemulsion or microemulsion, and the particle size of the dispersed phase droplet particles is generally 20-200 nm. Compared with ordinary emulsions, nanoemulsions have a larger specific surface area and free energy, which makes this type of emulsion an effective delivery system and is widely used in medicine, cosmetics and other fields. [0003] Vitamin antioxidants are natural antioxidants, among which vitamin C (VC) and vitamin E (VE) are the most widely used. Although there are a large number of reports on the use of VC and VE alone as antioxidant formulations at home and abroad, there are not many reports on the combined effect of the two. Studies have shown that the antioxidant activity of the two at the same time depends on the characteristics of the system. [0004] In 2011, M. Drach et al. studied the joi...

Claims

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Application Information

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IPC IPC(8): A61K31/375A61K31/355A61K8/67A61K8/31A61K8/06A61K9/107A61K47/06A61Q19/08A61P39/06A61P17/18
CPCA61K8/068A61K8/31A61K8/676A61K8/678A61K9/1075A61K31/355A61K31/375A61K47/44A61Q19/08A61K2300/00
Inventor 张晓红彭秋晨李姗冯伟许红岩郭荣
Owner YANGZHOU UNIV