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A compound orlistat composition preparation for weight loss of pets and its application

A technology of orlistat and its composition, which is applied in the field of compound orlistat composition preparations, to achieve the effects of easy production process, various administration forms, flexible administration methods and dosages

Active Publication Date: 2019-05-07
成都导飞科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] At present, there are no reports and applications of orlistat, statins and L-carnitine as a combination preparation for treating obese pets at home and abroad.

Method used

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  • A compound orlistat composition preparation for weight loss of pets and its application
  • A compound orlistat composition preparation for weight loss of pets and its application
  • A compound orlistat composition preparation for weight loss of pets and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-10

[0041] The prescription (powder, 100 g) of a compound orlistat composition preparation for weight loss and fat-lowering of pets of the present invention is as follows.

[0042] Table 1. Examples 1-10 formulations.

[0043]

[0044] The preparation method comprises the following steps: placing orlistat, statin compound, L-carnitine salt, beef essence or fish meat essence, and lactose in an oven for 2 hours, taking out the original drug powder, and passing through a 120-mesh sieve. Take an appropriate amount of lactose and grind it in a mortar to make the inner wall saturated, then pour it out, put orlistat and beef flavor (or fish meat flavor) in the mortar and grind them evenly, and gradually add pravastatin sodium according to the method of equal increase and mixing Grind thoroughly, then add L-carnitine hydrochloride in equal amount to fully grind, then gradually add the required lactose according to the method of equal amount incremental mixing, grind evenly, and finally...

Embodiment 11-20

[0046] The single-dose prescription (tablet) of a compound orlistat composition preparation for pet weight loss and lipid-lowering of the present invention is.

[0047] Table 2. Example 11-20 formulations.

[0048]

[0049] The preparation method includes the following steps: put the original drug powder orlistat and statin compounds, L-carnitine salt, filler, lubricant magnesium stearate and glidant micropowder silica gel in an oven for 2 hours to dry at 40 ° C, take out , respectively through a 120-mesh sieve. Take the prescribed amount of powder and mix thoroughly, and then directly press the powder into tablets.

Embodiment 21-30

[0051] The prescription (syrup, 100 mL) of a compound orlistat composition preparation for weight loss and fat-lowering of pets of the present invention is as follows.

[0052] Table 3. Example 21-30 formulations.

[0053]

[0054] The preparation method comprises the following steps: under the condition of normal temperature (25°C), the main drug orlistat, a statin compound and L-carnitine salt, a flavoring agent beef flavor / fish flavor, and a preservative benzoic acid are dissolved in a certain amount of distilled water ; Weigh the sucrose of prescription quantity, dissolve in a certain amount of distilled water under normal temperature stirring, filter to net. Mix the two parts of the solution and stir evenly at room temperature.

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Abstract

The invention discloses a compound orlistat composition preparation for pet slimming and application thereof, belongs to the field of veterinary drugs, and specifically relates to a pharmaceutical composition containing orlistat, statin compounds and L-carnitine. The pharmaceutical composition comprises the following components in parts by mass: 1-1000 parts of the orlistat, 1-500 parts of the statin compounds, and 1-50000 parts of the L-carnitine, wherein the pharmaceutical composition is one or a combination of a solid preparation including conventional tablets, dispersible tablets, sustained-release tablets, capsules, granules, powder and the like, a semi-solid preparation including ointment, paste, gel and the like, and a liquid preparation including syrup, an oral solution and the like. The compound orlistat composition preparation provided by the invention has an obvious synergistic action in treatment of obesity, and is significant in slimming effect, high in safety, simple in preparation method, convenient to operate, and suitable for industrial production.

Description

technical field [0001] The invention relates to a compound orlistat composition preparation for weight loss and fat-lowering of pets and application thereof. It belongs to the field of veterinary medicine. Background technique [0002] With the rapid development of social economy and the continuous improvement of people's living standards, the living and eating conditions of pets are becoming more and more superior. The obesity problem of pet dogs and cats is becoming more and more serious. It has become the number one problem threatening the health of pets and has attracted widespread attention. [0003] First, excess fat accumulation will inevitably affect the pet's appearance and animal welfare, reducing its quality of life. What's more serious is that the obesity problem itself is closely related to the occurrence of many diseases, including metabolic abnormalities such as hyperlipidemia, insulin resistance, fatty liver and glucose tolerance, etc., endocrine diseases s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K31/365A61K31/205A61K31/22A61K31/47A61P3/04
CPCA61K31/205A61K31/22A61K31/365A61K31/47A61K45/06A61K2300/00
Inventor 张凌
Owner 成都导飞科技有限公司
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