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Compound olaparib composition preparation for pet allergic skin disease

A technology of oclatinib and its composition, which is applied in the field of veterinary medicine, can solve problems such as a narrow range of action, and achieve the effects of simple production process, convenient operation, flexible administration method and dosage

Inactive Publication Date: 2019-08-23
成都导飞科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, although oclatinib has a better effect on allergic skin diseases in pet dogs, its scope of action is narrow. On the one hand, it has little effect on cytokines that do not participate in the activation of JAK1; The ultimate effect is only to inhibit the degranulation of mast cells, that is, the release of allergic mediators, and it cannot fundamentally directly block the combination of allergic mediators and related receptors, and it cannot fundamentally block the occurrence and development of allergic skin diseases

Method used

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  • Compound olaparib composition preparation for pet allergic skin disease
  • Compound olaparib composition preparation for pet allergic skin disease
  • Compound olaparib composition preparation for pet allergic skin disease

Examples

Experimental program
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Effect test

Embodiment 1-10

[0040] The prescription (powder, 100 g) of the compound oclatinib composition for pet allergic skin diseases of the present invention is as follows.

[0041] Table 2. Example 1-10 formulations.

[0042]

[0043] The preparation method comprises the following steps: placing the powdered oclacitinib, anti-H1 receptor antagonist, beef flavor or fish meat flavor, and lactose in an oven, drying at 40°C for 2 hours, taking them out, and passing through a 120-mesh sieve respectively. Take an appropriate amount of lactose and grind it in a mortar to make the inner wall saturated, then pour it out, put oclacitinib and beef flavor (or fish meat flavor) in the mortar and grind them evenly, and gradually add anti-H1 receptors by equal volume mixing method Grind the antagonists fully, then gradually add the required lactose according to the method of equal volume incremental mixing, knead evenly, and finally divide it into single-dose powder by weight method, and pack it.

Embodiment 11-20

[0045] A single-dose prescription (tablet, 100g / 1000 tablets) of the compound oclatinib composition preparation for pet allergic skin diseases of the present invention is.

[0046] Table 3. Example 11-20 formulations.

[0047]

[0048] The preparation method includes the following steps: place the original drug powder oclatinib, anti-H1 receptor antagonist, filler, lubricant magnesium stearate and glidant micropowder silica gel in an oven for 2 h at 40°C, take them out, and separate Pass through a 120 mesh sieve. Take the prescribed amount of powder and mix thoroughly, and then directly press the powder into tablets.

Embodiment 21-30

[0050] The prescription (syrup, 100 mL) of a compound oclatinib composition preparation for pet allergic skin diseases of the present invention is as follows.

[0051] Table 4. Example 21-30 formulations.

[0052]

[0053] The preparation method includes the following steps: under the condition of normal temperature (25°C), the main drug oclatinib, the anti-H1 receptor antagonist, the flavoring agent beef flavor / fish flavor, and the preservative benzoic acid are dissolved in a certain amount of distilled water; Take the prescribed amount of sucrose, dissolve it in a certain amount of distilled water with stirring at room temperature, and filter until it is clean. Mix the two parts of the solution and stir evenly at room temperature.

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Abstract

The invention discloses a compound oclatinib composition for allergic skin diseases of pets and its application, belongs to the field of veterinary medicine, and in particular relates to a pharmaceutical composition containing oclatinib and an anti-H1 receptor antagonist. It consists of the following components in parts by mass: 1-500 parts of oclatinib, and 1-200 parts of anti-H1 receptor antagonist. Among them, the pharmaceutical composition is solid preparations such as ordinary tablets, dispersible tablets, sustained-release tablets, capsules, granules, powders, etc., semi-solid preparations such as ointments, pastes, gels, etc., injections, syrups, oral solutions, etc. One or a combination of liquid preparations. The invention has obvious synergistic effect in the treatment of allergic skin diseases, has remarkable drug curative effect, high safety, simple preparation method and convenient operation, and is suitable for industrialized production.

Description

technical field [0001] The invention relates to a compound oclatinib composition preparation for allergic skin diseases of pets and application thereof. It belongs to the field of veterinary medicine. Background technique [0002] In recent years, pet breeding has increased year by year. The status of pets in people's families is gradually improving, and they play an increasingly important role in people's lives. However, while pets bring a lot of happiness to every family, allergic skin diseases cause many troubles for people. On the one hand, allergic skin disease is a common multiple disease of pets, and it is also one of the most important diseases that are most easily transmitted to humans. Due to the close contact between people and pets, the skin health of pets has a non-negligible impact on people's health. The contagiousness of pet allergic dermatosis to humans is worrying. On the other hand, pets suffering from allergic skin diseases scratch their ears and chee...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/519A61K31/4402A61K31/4418A61K31/135A61K31/495A61K31/4545A61K31/506A61K31/445A61K31/4439A61K9/20A61K9/08A61P37/08A61P17/00
Inventor 张凌
Owner 成都导飞科技有限公司
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