Compound olaparib composition preparation for pet allergic skin disease

Abstract

The invention discloses a compound olaparib composition preparation for pet allergic skin disease and application thereof, belongs to the field of veterinary drug, and particularly relates to a drug composition containing, by mass, 1-500 parts of olaparib and 1-200 parts of anti-H1-acceptor antagonist. The drug composition is one of or a combination of multiple of solid preparations like conventional tablets, dispersible tablets, sustained-release tablets, capsules, granules and powder, semi-solid preparations like ointment, paste and gel and liquid preparations like injections, syrups and oral solutions. The compound olaparib composition has obvious synergism in the aspect of treating allergic skin disease and is remarkable in treatment effect and high in safety, and a preparation methodof the composition is simple, convenient to operate and suitable for industrial production.

Description

Technical field

[0001] The invention relates to a compound olatinib composition preparation for pet allergic skin diseases and its application. It belongs to the field of veterinary medicine. Background technique

[0002] In recent years, pet keeping has increased year by year. The status of pets in people's families is gradually improving, and they are playing an increasingly important role in people's lives. However, while pets bring a lot of happiness to every family, allergic skin diseases cause people a lot of trouble. On the one hand, allergic skin disease is a common multiple disease in pets, and it is also one of the most important diseases that are most easily transmitted to people. Due to the close contact between people and pets, the skin health of pets has a significant impact on people’s health. The infectiousness of pet allergic skin diseases to humans is worrying. On the other hand, pets suffering from allergic skin diseases scratch their ears and cheeks all da...

Examples

Embodiment 1-10

[0040] The prescription (powder, 100 g) of a compound olatinib composition for pet allergic skin diseases of the present invention is:

[0041] Table 2. Formulations of Examples 1-10.

[0042]

[0043] The preparation method includes the following steps: placing the powdered original drug olatinib and the anti-H1 receptor antagonist, beef flavor or fish flavor, and lactose in an oven at 40° C., drying for 2 h, taking them out, and passing them through a 120-mesh sieve. Take an appropriate amount of lactose and grind it in a mortar to saturate the inner wall and pour it out. Place the olatinib and beef flavor (or fish flavor) in the mortar and mix evenly, and gradually add the anti-H1 receptor according to the same amount of addition and mixing method The antagonist is fully grinded, and then the required lactose is gradually added according to the equal volume adding and mixing method, and the mixture is uniformly mixed. Finally, the antagonist is divided into single-dose powders ...

Embodiment 11-20

[0045] The single-dose prescription (tablet, 100g / 1000 tablets) of a compound olatinib composition preparation for pet allergic skin diseases of the present invention is.

[0046] Table 3. Formulations of Examples 11-20.

[0047]

[0048] The preparation method includes the following steps: placing the original powder of olatinib and anti-H1 receptor antagonist, filler, lubricant magnesium stearate and glidant micropowder silica gel in an oven at 40°C and drying for 2 hours, taking them out, respectively Pass through a 120 mesh sieve. After taking the prescribed amount of powder and mixing thoroughly, the powder is directly pressed into tablets.

Embodiment 21-30

[0050] The prescription (syrup, 100 mL) of a compound olatinib composition preparation for pet allergic skin diseases of the present invention is:

[0051] Table 4. Recipes for Examples 21-30.

[0052]

[0053] The preparation method includes the following steps: Dissolve the main drug olatinib, anti-H1 receptor antagonist, beef flavor / fish flavor, and preservative benzoic acid in a certain amount of distilled water under normal temperature conditions (25°C); Take the prescribed amount of sucrose, dissolve it in a certain amount of distilled water under stirring at room temperature, and filter until clean. Mix the two parts of the solution and stir evenly at room temperature.

Technical field

[0001] The invention relates to a compound olatinib composition preparation for pet allergic skin diseases and its application. It belongs to the field of veterinary medicine. Background technique

[0002] In recent years, pet keeping has increased year by year. The status of pets in people's families is gradually improving, and they are playing an increasingly important role in people's lives. However, while pets bring a lot of happiness to every family, allergic skin diseases cause people a lot of trouble. On the one hand, allergic skin disease is a common multiple disease in pets, and it is also one of the most important diseases that are most easily transmitted to people. Due to the close contact between people and pets, the skin health of pets has a significant impact on people’s health. The infectiousness of pet allergic skin diseases to humans is worrying. On the other hand, pets suffering from allergic skin diseases scratch their ears and cheeks all da...

Examples

Embodiment 1-10

[0040] The prescription (powder, 100 g) of a compound olatinib composition for pet allergic skin diseases of the present invention is:

[0041] Table 2. Formulations of Examples 1-10.

[0042]

[0043] The preparation method includes the following steps: placing the powdered original drug olatinib and the anti-H1 receptor antagonist, beef flavor or fish flavor, and lactose in an oven at 40° C., drying for 2 h, taking them out, and passing them through a 120-mesh sieve. Take an appropriate amount of lactose and grind it in a mortar to saturate the inner wall and pour it out. Place the olatinib and beef flavor (or fish flavor) in the mortar and mix evenly, and gradually add the anti-H1 receptor according to the same amount of addition and mixing method The antagonist is fully grinded, and then the required lactose is gradually added according to the equal volume adding and mixing method, and the mixture is uniformly mixed. Finally, the antagonist is divided into single-dose powders ...

Embodiment 11-20

[0045] The single-dose prescription (tablet, 100g / 1000 tablets) of a compound olatinib composition preparation for pet allergic skin diseases of the present invention is.

[0046] Table 3. Formulations of Examples 11-20.

[0047]

[0048] The preparation method includes the following steps: placing the original powder of olatinib and anti-H1 receptor antagonist, filler, lubricant magnesium stearate and glidant micropowder silica gel in an oven at 40°C and drying for 2 hours, taking them out, respectively Pass through a 120 mesh sieve. After taking the prescribed amount of powder and mixing thoroughly, the powder is directly pressed into tablets.

Embodiment 21-30

[0050] The prescription (syrup, 100 mL) of a compound olatinib composition preparation for pet allergic skin diseases of the present invention is:

[0051] Table 4. Recipes for Examples 21-30.

[0052]

[0053] The preparation method includes the following steps: Dissolve the main drug olatinib, anti-H1 receptor antagonist, beef flavor / fish flavor, and preservative benzoic acid in a certain amount of distilled water under normal temperature conditions (25°C); Take the prescribed amount of sucrose, dissolve it in a certain amount of distilled water under stirring at room temperature, and filter until clean. Mix the two parts of the solution and stir evenly at room temperature.

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