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Medicine composition for treating and/or auxiliarily treating osteoarticular diseases and preparation method thereof

A technology for bone and joint disease and adjuvant treatment, applied in the directions of drug combination, bone disease, pharmaceutical formula, etc., can solve problems such as unsatisfactory curative effect, and achieve the effect of controlling knee osteoarthritis and reasonable compatibility.

Active Publication Date: 2017-07-21
THE AFFILIATED HOSPITAL OF TRADITIONAL CHINESE MEDICAL TO SOUTHWEST MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the curative effect of clinically used drugs for treating KOA is still not satisfactory, and new drugs with significant curative effects are urgently needed

Method used

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  • Medicine composition for treating and/or auxiliarily treating osteoarticular diseases and preparation method thereof
  • Medicine composition for treating and/or auxiliarily treating osteoarticular diseases and preparation method thereof
  • Medicine composition for treating and/or auxiliarily treating osteoarticular diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1 Preparation of the composition of the present invention

[0043] Prescription: Clematis 600g, Paeoniae Alba 600g, Fangji 600g, Astragalus 400g, Corydalis 200g, Scorpio 60g, Centipede 3g, Asarum 80g, Borneol 30g.

[0044] Preparation Process:

[0045] (1) Weigh each bulk drug according to the prescription;

[0046] (2) Soak the scorpion, centipede, Fangji, and Corydalis 4 herbs with 5 times the amount of 60% ethanol for 7 days, filter, reclaim the ethanol from the filtrate and condense it into a liquid extract, and set aside;

[0047] (3) Take the filter residue of the four herbs, add Clematis, Radix Paeoniae Alba, Radix Astragali, Asarum, add 7 times the amount of water to soak for 0.5 hours, decoct twice, 1 hour each time. Combine the decoctions, filter, concentrate the filtrate under reduced pressure to a relative density of 1.02-1.05 (80°C), let stand for 12 hours, filter, concentrate the filtrate under reduced pressure to a clear paste with a relative...

Embodiment 2

[0050] Embodiment 2 Preparation of the composition of the present invention

[0051] Prescription: Clematis 480g, Paeoniae Alba 480g, Fangji 480g, Astragalus 320g, Corydalis 160g, Scorpio 78g, Centipede 4g, Asarum 104g, Borneol 39g.

[0052] Preparation process: with the preparation process of embodiment 1.

Embodiment 3

[0053] Embodiment 3 Preparation of the composition of the present invention

[0054] Prescription: Clematis 720g, Paeoniae Alba 720g, Fangji 720g, Astragalus 480g, Corydalis 240g, Scorpion 42g, Centipede 2g, Asarum 56g, Borneol 21g.

[0055] Preparation process: with the preparation process of embodiment 1.

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Abstract

The invention provides a medicine composition for treating and / or auxiliarily treating osteoarticular diseases. The medicine composition is prepared by the following raw materials in parts by weight: 480-720 parts of radix clematidis, 480-720 parts of white paeony root, 480-720 parts of the root of fangji, 320-480 parts of astragalus mongholicus, 160-240 parts of rhizoma corydalis, 42-78 parts of scorpio, 2-4 parts of centipede, 56-104 parts of asarum and 21-39 parts of borneol. The invention also provides a preparation method and an application of the composition. The composition provided by the invention is reasonable in compatibility, has the effects of dispelling wind and removing obstruction in the meridians, relieving pain, reinforcing qi and nourishing blood, and promoting blood circulation, and significant effect of improving osteoarticular degeneration, and can effectively delay and control knee osteoarthritis, and thus a new medicine selection is provided for clinic.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating and / or assisting the treatment of bone and joint diseases, its preparation method and application. Background technique [0002] Knee osteoarthritis (KOA) is a chronic, progressive osteoarthritis that mostly occurs in middle-aged and elderly people. With the aging of the social population, its incidence is on the rise, ranking first in the geriatric diseases worldwide. The characteristic change of KOA is progressive cartilage degeneration, which will eventually lead to loss of joint function and seriously affect the health and quality of life of patients. [0003] Since the initial and main lesion site of KOA is cartilage, it can be deduced that the lesion of chondrocytes will have an important impact on KOA, and delaying the degeneration of articular cartilage is of great significance for the prevention and treatment of bone and joint diseases. [0004] Currently, the curative effect ...

Claims

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Application Information

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IPC IPC(8): A61K36/716A61P19/02A61P19/08A61K35/646A61K35/648A61K31/045
CPCA61K31/045A61K35/646A61K35/648A61K36/268A61K36/481A61K36/59A61K36/65A61K36/66A61K36/71A61K36/716A61K2236/33A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 黄淑芬张琼张茂平胡琼丹李小军赵长英曾炎陈定国
Owner THE AFFILIATED HOSPITAL OF TRADITIONAL CHINESE MEDICAL TO SOUTHWEST MEDICAL UNIV
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