Evaluation method for improvement effect of traditional Chinese medicine component on azithromycin action baseline, and applications of evaluation method in evaluation of Fukeqianjin prescription

Abstract

The invention discloses an evaluation method for the improvement effect of a traditional Chinese medicine component on an azithromycin action baseline, and applications of the evaluation method in evaluation of a Fukeqianjin prescription. According to the present invention, a baseline equal addition method is used, wherein the action level of the exact and effective treatment drug azithromycin is determined, the azithromycin and a tested traditional Chinese medicine composition are administered to experiment models in a parallel manner, the baseline level of the combination medication and the treatment effect trend of the of the combination medication are determined, a group pharmacokinetics-group pharmacodynamics combined model is established, and verification is performed; the pharmacokinetics-pharmacodynamics system variation dynamics system capable of quantitatively evaluating the participation of the medicinal guide is scientifically designed, and the disadvantage of the application of the weak efficacy drug treatment effect index point method to determine mean value comparison in the research method is changed; with the application of the evaluation method of the present invention in the evaluation of the improvement of the Fukeqianjin prescription, the synergetic effect of the Fukeqianjin prescription composition on each pharmacokinetic parameter of the azithromycin can be defined, and the main drug group providing effects of anti-inflammation and blood circulation activating in the Fukeqianjin prescription composition can be summarized and obtained; and the evaluation method can be well used for evaluating the safety and the effectiveness of the combination of the traditional Chinese medicine composition and the antibiotics, particularly for evaluating the internal elimination effect of the angelica sinensis component medicinal guide in the Fukeqianjin prescription.

Description

technical field [0001] The present invention relates to the technical field of drug evaluation, more specifically, to a method for evaluating the baseline enhancement level of azithromycin by active ingredients in a traditional Chinese medicine composition, especially an evaluation method for the baseline enhancement level of azithromycin by active ingredients in the traditional Chinese medicine composition Fuke Qianjin Fang. [0002] technical background [0003] According to literature reports, traditional Chinese medicine believes that the main mechanism of chronic pelvic inflammatory disease (CPID) is that women's blood chambers are opening during menstruation and postpartum, and the remaining blood is not exhausted. Affect Chong Ren Qi and blood to cause stasis. [0004] In recent years, with the acceleration of the modernization process of traditional Chinese medicine, the combined application of Chinese and Western medicine has become increasingly widespread. The clin...

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Problems solved by technology

[0008] However, in the research on the combined application of Fukeqianjin Tablets and antibiotics in the treatment of chronic pelvic inflammatory disease, there are few studies on the existence, internal mechanism and effect of Angelica in Fukeqianjin Fang. The effect is based on the effect of which active ingredient group is used in Baiduhuadu. There is also a lack of relevant research and guidance on the mechanism of how the active ingredient and active ingredient group in Fukeqianjin Tablets can improve the baseline level of azithromycin.

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