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Method for preparing metoprolol succinate sustained-release pellet tablets

A technology of metoprolol succinate and sustained-release pellets, applied in the field of medicine, can solve the problems of long production time and high cost

Inactive Publication Date: 2017-09-12
广西厚德大健康产业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And the existing preparation technology of metoprolol succinate sustained-release tablets has a long production time and high cost

Method used

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  • Method for preparing metoprolol succinate sustained-release pellet tablets
  • Method for preparing metoprolol succinate sustained-release pellet tablets
  • Method for preparing metoprolol succinate sustained-release pellet tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Prescription:

[0022]

[0023]

[0024] (2) Make every tablet of 47.5mg metoprolol succinate according to (1) prescription, the preparation method of this sheet is as follows:

[0025] The pellets of this product are divided into three layers. From the inside to the outside, there are microcrystalline cellulose pellet core, drug layer, and slow-release anti-pressure layer. Due to the limitation of equipment capacity and coating time, the drug layer can be divided into two or more layers. Three times done. (The coating equipment is a multi-kinetic fluidized bed coating machine)

[0026] Drug layer coating: take metoprolol succinate, add purified water at 50-60°C, stir to dissolve, then add hyprolose EF, stir to dissolve, and obtain a coating with a solid content of 10.30%-27.8% liquid. Add the microcrystalline cellulose pellet core CP203 into the fluidized bed, adjust the temperature of the material at 38°C±5°C, the relative humidity of the material at 20%-...

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Abstract

The invention belongs to the technical field of medicine and relates to a method for preparing metoprolol succinate sustained-release pellet tablets. The method includes steps: dissolving metoprolol salt and a bonding agent into an appropriate solvent to prepare coating solution for a medicine layer; dissolving a sustained-release coating material, a plasticizer and a pore forming agent of a sustained-release compression-resistant layer into coating solution solvent to prepare coating solution for the sustained-release layer; adding appropriate auxiliary materials, well mixing, tabletting and coating. The metoprolol succinate sustained-release pellet tablets keep active component release speed unchanged even being split for administration, and active components can be continuously and slowly released within 24 hours.

Description

technical field [0001] The invention relates to a method for preparing metoprolol succinate sustained-release pellets for tableting, and belongs to the technical field of medicine. Background technique [0002] Heart disease is a relatively common circulatory system disease. Metoprolol is a selective β1-receptor blocker, and the dose required for its effect on cardiac β1 receptors is lower than that required for its effect on peripheral vascular and bronchial β2 receptors. The selectivity of metoprolol succinate is dose-dependent, because the peak blood concentration of sustained-release tablets is significantly lower than that of ordinary plain tablets of the same dose, so that this dosage form has relatively higher β1 receptor selectivity. Metoprolol has no β-receptor agonism and almost no membrane activation. Beta-blockers have negative inotropic and chronotropic effects. Treatment with metoprolol attenuates the effects of catecholamines associated with physical and ps...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/50A61K9/52A61K47/38A61K31/138A61P9/00
CPCA61K9/2054A61K9/0002A61K9/2095A61K9/5015A61K9/5026A61K9/5042A61K9/5078A61K31/138
Inventor 季国明李品张树祥阮碧芳滕丽佳
Owner 广西厚德大健康产业股份有限公司
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