Hypertension liver-yang hyperactivity rat model discrimination method and application thereof

A technology for hyperactivity of liver yang and hypertension, applied in the field of medicine, can solve the problems of lack of control group, in-depth study of pharmacological mechanism, objective description of difficult syndromes, etc.

Active Publication Date: 2017-10-13
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

The simple superposition of several physical and chemical indicators is used to explain the syndrome of hyperactivity of liver yang. This inconsistency in the corresponding levels makes it difficult to describe the syndrome objectively.
Secondly, when refuting the animal model of hyperactivity of liver-yang syndrome in hypertension, one should carefully select a prescription that is effective and has a clear mechanism, so as to use this as a basis to observe the effect of the prescription after the model, and judge whether the established animal model has The nature of hyperactivity of liver-yang syndrome in hypertension, and the anti-symbol prescriptions currently used in clinical practice are mostly clinical empirical prescriptions, and their pharmacological mechanisms have not been studied in depth
In addition, when looking back at the previous method of "testing syndromes with prescriptions", usually only the normal group, the hypertensive liver-yang hyperactivity syndrome group (model group) and the syndrome-testing prescription group were set up, and there was often a lack of a control group. The efficacy obtained by the prescription cannot be simply judged as the attribute of the syndrome

Method used

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  • Hypertension liver-yang hyperactivity rat model discrimination method and application thereof
  • Hypertension liver-yang hyperactivity rat model discrimination method and application thereof
  • Hypertension liver-yang hyperactivity rat model discrimination method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1 Construction of Discrimination Method

[0042] 1. Experimental materials

[0043] (1) Experimental animals

[0044] 56 8-week-old male SHR rats (spontaneous hypertensive rats (SHR)) of SPF grade, weighing 186.35±8.15g, 7 male WKY rats of SPF grade 8 weeks old, weighing 190.15±6.37g, all purchased from Beijing Weiwei Tonglihua Experimental Animal Technology Co., Ltd. (SCXK (Beijing): 2012-0001). SHR was randomly divided into disease-syndrome group (DS Group), disease-syndrome Uncaria group (DSGT Group), disease-syndrome Gastrodia elata group (DSTM Group), disease-syndrome Shijuming group (DSSJM Group), model group (MGroup), model hook Rattan group (MGT Group), model Gastrodia elata group (MTM Group), model Shicaia group (MSJM Group), and WKY as normal group (Normal Group, N Group). 7 in each group.

[0045] (2) Experimental drugs

[0046] The medicinal materials of Fuzi, Uncaria, Gastrodia elata, and Cassia chinensis were purchased from Bozhou Huqiao Pharm...

Embodiment 2

[0170] Embodiment 2 Verification of discrimination method

[0171] In order to test the predictive ability of the constructed model for unknown samples, this study introduced 7 independent samples as the test set during the modeling, which were randomly selected samples from 1 disease syndrome group and 6 samples from drug intervention group, so that The objectivity of the predictive ability of the constructed model is guaranteed. see results Figure 10 , it can be seen that the model group and the syndrome group are clearly separated, indicating that the pathological conditions of SHR and hypertensive rats with hyperactivity of liver-yang syndrome are different. PLS Model R 2 Y is 99.0%, Q 2 It is 97.9%, indicating that the model has good predictive ability and high predictive accuracy. At the same time, it can be observed that one syndrome sample in the test set accurately falls in the syndrome group area, while the six drug intervention groups are separated from the syn...

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Abstract

The invention provides a hypertension liver-yang hyperactivity rat model discrimination method. According to the discrimination method, discrimination indexes are comprehensive, and special material groups generated in the hypertension liver-yang hyperactivity occurrence and development process are included. The method comprises the steps that a hypertension liver-yang hyperactivity rat model is copied as a disease group, macroscopic and biochemical physical indexes are measured, data is selected and brought into the hypertension liver-yang hyperactivity rat PLS regression model, if the disease group and the model group in a PLS two-dimensional score plot are separated, the built hypertension liver-yang hyperactivity rat model is successful, and if not, the built hypertension liver-yang hyperactivity rat model is not successful.

Description

technical field [0001] The invention belongs to the technical field of medicine, and the invention relates to a rat model discrimination method of hypertensive liver-yang syndrome and its application. The method is used for evaluating the hypertensive rat model of liver-yang hyperactivity. Background technique [0002] Combination of disease and syndrome animal models refers to the combination of modern medical theory and experimental animal science knowledge under the guidance of traditional Chinese medicine theory, respectively or at the same time, using traditional Chinese medicine etiology to replicate syndrome animal models and modern medical etiology to replicate disease animal models to make animals The model can not only reflect the pathological characteristics of the disease, but also systematically and dynamically reflect the syndrome characteristics that appear in this specific stage. Syndrome of hyperactivity of liver-yang in hypertension is a common syndrome typ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/00G06F19/24A61B5/0205A61B5/00
CPCA61B5/02055A61B5/021A61B5/4827A61B2503/40A61B2503/42G16B40/00
Inventor 李运伦杨雯晴齐冬梅蒋海强
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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