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Intestinal microbiota and gvhd

A technology of compositions and mixtures, applied in the fields of biochemical equipment and methods, determination/inspection of microorganisms, analysis of biological materials, etc.

Pending Publication Date: 2017-10-13
MEMORIAL SLOAN KETTERING CANCER CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Recipients of this type of transplant have a much lower risk of developing GVHD

Method used

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  • Intestinal microbiota and gvhd
  • Intestinal microbiota and gvhd
  • Intestinal microbiota and gvhd

Examples

Experimental program
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Effect test

Embodiment

[0093] Patient Selection and Specimen Collection Methods

[0094] In one study, subjects who underwent all-HSCT at Memorial Sloan Kettering Cancer Center (MSKCC) between 1994 and 2013 were retrospectively analyzed for the effect of antibiotics on clinical outcomes. Consists of 283 adult patients. Patients who received conventional grafts (non-T cell-depleted) were included in this study; patients who received ex vivo T-cell-depleted grafts or peritransplantation alemtuzumab were excluded. During the transplant hospitalization, weekly stool samples were collected and stored. The study was approved by the Institutional Review Board of MSKCC. All study patients provided written informed consent for the collection and analysis of biological specimens.

[0095] GVHD is diagnosed clinically, confirmed pathologically by biopsy when possible, and classified according to historical consensus criteria as previously described (see Rowlings PA, Przepiorka D, Klein JP et al, "For the ma...

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Abstract

The present disclosure describes compositions and methods for increasing the abundance of commensal bacteria belonging to the order Clostridiales, including Blautia, Ruminococcus, Clostridium, Eubacterium, Holdemania and Dorea species, that are as-sociated with reduced lethal GVHD and improved overall survival following bone mar-row or hematopoietic stem cell transplant. The present disclosure, therefore, provides methods for reducing the likelihood, incidence or severity of GVHD by (1) avoiding the loss of endogenous beneficial species through antibiotic selection; (2) by administering a therapeutically effective amount of a composition comprising one or more Clostridiales associated with reduced GVHD to individuals who may lack or have lost those strains from their intestinal microbiota. Additionally, support for endogenous or reestablished Clostridiales related to reduced GVHD as a treatment option for reducing GVHD can also be provided in the form of nutritional supplementation, for example, sugars fermented by some species of Clostridiales with GVHD reducing activity.

Description

[0001] Statement Regarding Federally Sponsored Research or Development [0002] This invention was made with U.S. Government support under grant numbers R01HL069929, R01-AI080455, R01-AI100288, R01-AI101406, P01-CA023766, and P01-CA023766 from the National Institutes of Health and the National Institutes of Allergy and Infectious Diseases Contract HHSN272200900059C of the U.S. National Institute of Allergy and Infectious Disease. The government has certain rights in this invention. technical field [0003] The present invention relates generally to Graft Versus Host Disease (GVHD). More specifically, the present invention relates to the role of gut microbiota as a predictor of GVHD severity / mortality and informs strategies for reducing GVHD-related morbidity. Background technique [0004] Although outcomes for patients undergoing allogeneic bone marrow transplantation (allo BMT) continue to improve, GVHD remains the leading cause of death in this population 1 . Modern i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61P37/06
CPCA61K38/14A61K35/28A23L33/10G01N2333/33G01N2800/245G01N2800/50A23L33/135A61K31/122A61K31/407A61K31/4164A61K31/427A61K31/431A61K31/496A61K31/505A61K31/5383A61K31/546A61K31/635A61K31/7042A61K35/74A61K9/0031A61K9/0053A61K31/43A61K45/06C12Q2600/118C12Q1/689A61K31/715C12Q1/6883A61P35/00A61K31/70A61K2300/00C12Q1/68A61K47/26G01N33/56911
Inventor M·万登布林克R·耶齐E·G·帕默Y·陶勒Y·庄野
Owner MEMORIAL SLOAN KETTERING CANCER CENT
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