Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of nutmeg lignan to preparation of liver protection drugs

A nutmeg lignan, liver protection technology, applied in the directions of drug combination, digestive system, ether/acetal active ingredients, etc., to achieve the effect of maintaining integrity, inhibiting inflammation, and reducing liver damage

Inactive Publication Date: 2017-11-03
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of macelignan for liver injury diseases has not been reported so far.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of nutmeg lignan to preparation of liver protection drugs
  • Application of nutmeg lignan to preparation of liver protection drugs
  • Application of nutmeg lignan to preparation of liver protection drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Myristicolignan is extracted from the dried kernels of Myristicaceae Myristicaceae. The manufacturer is Nanchang Beta Biotechnology Co., Ltd. (batch number 20049‐201507). The structural formula is:

[0024]

[0025] Therapeutic effect of macelignan on TAA-induced acute liver injury in mice:

[0026] Animals: C57BL / 6 mice, SPF grade, 37 to 40 days old, weighing 20 to 22 g, male; all certificate numbers are: SCXK (Xiang) 2013‐0004, purchased from Hunan Slake Jingda Experimental Animal Co., Ltd.

[0027] Drugs and reagents: macelignan, colorless amorphous crystalline powder, Nanchang Beta Biotechnology Co., Ltd., batch number 20049‐201507. Aspartate Aminotransferase (AST) Kit (Cat. No. C010‐3, Lot No. 20161031), Alanine Aminotransferase (ALT) Kit (Cat. No. C009‐3, Lot No. 20161031) are from Nanjing Jiancheng Institute of Bioengineering Production. Thioacetamide (TAA, product number C1290-25G, batch number 1002213299) and sodium carboxymethylcellulose (product number 4...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of a nutmeg lignan to preparation of liver protection drugs. The nutmeg lignan has the obvious function of protecting liver in a mouse thioacetamideinduce (TAA) induced acute liver injury model, can remarkably reduce levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in acute liver injury animal model plasma, restrains poisonous substance from injuring liver cell membranes, relieves inflammation of liver cells and can create good economic benefits and wide social benefits when bring applied to research and development of the liver protection drugs.

Description

Technical field: [0001] The invention belongs to the technical field of liver damage medicines, and in particular relates to the application of macelignan as a medicine for treating acute liver damage caused by toxic chemicals. Background technique: [0002] Chemical liver injury refers to liver injury caused by chemical hepatotoxic substances. These chemicals include alcohol, chemical toxins in the environment, and certain drugs. As the largest and most important detoxification organ of the human body, the liver has a strong defense and detoxification function against toxic substances from outside the body and from the body's own metabolism. In addition, since the liver has dual blood supply of the hepatic artery and the hepatic vein, chemical substances can enter the liver through the portal vein of the gastrointestinal tract or the systemic circulation for transformation, so the liver is very vulnerable to damage from toxic substances of chemicals. In the modern industr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/09A61P1/16
CPCA61K31/09
Inventor 李飞杨晓男吕倩倩
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com