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Agent for preventing reduction in production of collagen, and external composition for skin and cosmetic each comprising same

A product, collagen technology, applied in the field of inhibitors, to achieve the effect of improving QOL, preventing or improving wrinkles, and improving elasticity

Inactive Publication Date: 2017-11-10
COMBI CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the extract used here is obtained by extracting the bird's nest with hot water and removing the solid content, and it is obviously different from the enzymatic hydrolyzate of bird's nest that is used directly by enzymatically treating the whole bird's nest

Method used

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  • Agent for preventing reduction in production of collagen, and external composition for skin and cosmetic each comprising same
  • Agent for preventing reduction in production of collagen, and external composition for skin and cosmetic each comprising same
  • Agent for preventing reduction in production of collagen, and external composition for skin and cosmetic each comprising same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0069] The present invention will be specifically explained based on the following examples, but the present invention is not limited to these examples.

[0070] (1) Preparation of bird's nest sample

[0071] (1-1) Bird's Nest Enzymatic Hydrolysate 1

[0072] The commercially available non-bleached bird's nest is pulverized with a pulverizer to obtain a bird's nest powder with a 100 mesh pass (particle size of 150 μm or less). Add about 50 times the amount (mass) of water to the bird's nest powder and swell at 5°C for 20 Hours, then heat sterilization at 121°C for 15 minutes.

[0073] After cooling the obtained treatment liquid, the pH was adjusted, and a protease-containing enzyme (trade name "Pankurayan F", manufactured by Amano Pharmaceutical Co., Ltd.) was added in an amount of 2% by mass relative to the bird's nest powder, and reacted at 45°C for 3 hours.

[0074] The enzyme reaction solution was adjusted to pH 7.0, then heated at 90°C for 5 minutes to inactivate the enzyme, filt...

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Abstract

Disclosed is an agent for preventing the reduction in the production of collagen, which comprises an enzymatically decomposed product of swallow's nest as an active ingredient, and is an agent for preventing the reduction in the production of collagen in a dermal fibroblast caused by the irradiation with an ultraviolet light. Specifically disclosed are: an excellent agent for preventing the reduction in the production of collagen in a dermal fibroblast, which can be produced with high efficiency and is highly safe; and an external preparation and a cosmetic, each of which comprises the agent.

Description

[0001] This application is a divisional application of a patent application whose application date is June 21, 2010, the application number is 201080028249.3, and the invention title is "collagen production reduction inhibitor, skin external use composition and cosmetics containing the collagen production reduction inhibitor" . [0002] Reference to related applications [0003] This application is based on Japanese Patent Application No. 2009-148772 (filing date: June 23, 2009) filed first, and claims the benefit of priority, and the entire disclosure of the content is incorporated herein by reference. Technical field [0004] The present invention relates to an inhibitor for reducing the production of collagen in dermal fibroblasts using a bird's nest enzymatic hydrolysate as an active ingredient. More specifically, the present invention relates to a collagen production reduction inhibitor that inhibits the reduction in the production of type I collagen that occurs in skin dermal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/98A61Q19/02A61Q17/04A61Q19/08A61K35/12A61K35/57A61K36/06A61P17/16A61P43/00
CPCA61K8/981A61Q17/04A61Q19/02A61Q19/08A61P17/16A61P43/00
Inventor 武川和琴渡边卓巳
Owner COMBI CORP
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