Performance-improved injection implant

A technology for injecting implants and volatile solvents, which is applied in the field of polylactic acid injection implants to achieve the effects of reducing irritation reactions, reducing the incidence of adverse reactions and enhancing effects

Inactive Publication Date: 2017-11-10
江苏西宏生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the anesthesia effect of lidocaine is difficult to maintain for several days, and it needs to be made into a sustained release preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Its composition (formulation) is as follows:

[0046]

[0047] Among them, L-polylactic acid : The weight average molecular weight is 80,000 to 140,000, and the (average) particle size is 30 to 50 microns;

[0048] Poly-lactide-glycolide (1:2) : The weight-average molecular weight is 0.6-0.8 million, and the (average) particle size is 10-25 microns;

[0049] The (average) particle size of lidocaine particles is 50nm to 100nm;

[0050] The average molecular weight of polygelatin is 27500-39500.

[0051] Preparation:

[0052] 1. Preparation of polylactic acid Microsphere Ⅰ:

[0053] 1), the biodegradable polymer PLA Dissolved in 10 times the weight of the volatile solvent dichloromethane to obtain solution 1, cooled to below 20°C;

[0054]2) Mix an aqueous solution containing 8% (wt / wt) emulsifier Tween 80 equivalent to 3 times the volume of solution 1 with solution 1 to make an emulsion;

[0055] 3), evaporate the volatile solvent in the above-mentioned e...

Embodiment 2

[0089] Its composition (formulation) is as follows:

[0090]

[0091] Among them, L-polylactic acid : The weight average molecular weight is 130,000 to 160,000, and the (average) particle size is 20 to 40 microns;

[0092] Poly-lactide-glycolide (1:2) : The weight-average molecular weight is 0.6-0.8 million, and the (average) particle size is 10-15 microns;

[0093] Lidocaine particles have a (average) particle size of 5 nm to 20 nm;

[0094] The average molecular weight of polygelatin is 180,000-250,000.

[0095] Preparation:

[0096] Same as Example 1.

Embodiment 3

[0098] Its composition (formulation) is as follows:

[0099]

[0100] Among them, L-polylactic acid : The weight average molecular weight is 130,000 to 160,000, and the (average) particle size is 20 to 40 microns;

[0101] Poly-lactide-glycolide (1:2) : The weight-average molecular weight is 0.6-0.8 million, and the (average) particle size is 10-15 microns;

[0102] Lidocaine particles have a (average) particle size of 5 nm to 20 nm;

[0103] The average molecular weight of polygelatin is 27500-39500.

[0104] Preparation:

[0105] Same as Example 1.

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Abstract

The invention discloses a performance-improved injection implant. The injection implant consists of a polylactic acid (1) microsphere I which is basically free from lidocaine, a polylactic-co-glycolic acid (1: 2) (2) microsphere II which contains lidocaine granules and can achieve continuous release for 10-14 days basically at 0 level and polygeline. The injection implant (filled) is more lasting in effect and lower in side effects, and relatively high needle passing performances and redissolving (reconstruction) performances can be guaranteed.

Description

technical field [0001] The invention relates to an injection implant. Specifically, it relates to a performance-improved polylactic acid injection implant. technical background [0002] PLLA poly-L-lactic acid has been used in the medical field as a dissolvable surgical suture for more than 30 years. Since 1999, it has been widely used as a medical aesthetic injection product in more than 46 countries. This substance is derived from fruit acid, which will eventually be decomposed into lactic acid, carbon dioxide and water in the body, and then absorbed by the body naturally without remaining in the body. [0003] PLLA poly-L-lactic acid is injected into the deep part of the skin to stimulate the production of self-generated collagen. After a course of injection, it can replenish a large amount of lost collagen, fill the sunken part, improve facial wrinkles and pit lines from shallow to deep, and achieve maintenance A more refined and youthful appearance to the face. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/48A61L27/54A61L27/58
CPCA61L27/48A61L27/54A61L27/58A61L2300/204A61L2300/604A61L2300/622A61L2300/624A61L2400/06C08L67/04C08L89/00
Inventor 丁劲松付东山王志强徐增松
Owner 江苏西宏生物医药有限公司
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