Performance-improved injection implant
A technology for injecting implants and volatile solvents, which is applied in the field of polylactic acid injection implants to achieve the effects of reducing irritation reactions, reducing the incidence of adverse reactions and enhancing effects
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Embodiment 1
[0045] Its composition (formulation) is as follows:
[0046]
[0047] Among them, L-polylactic acid : The weight average molecular weight is 80,000 to 140,000, and the (average) particle size is 30 to 50 microns;
[0048] Poly-lactide-glycolide (1:2) : The weight-average molecular weight is 0.6-0.8 million, and the (average) particle size is 10-25 microns;
[0049] The (average) particle size of lidocaine particles is 50nm to 100nm;
[0050] The average molecular weight of polygelatin is 27500-39500.
[0051] Preparation:
[0052] 1. Preparation of polylactic acid Microsphere Ⅰ:
[0053] 1), the biodegradable polymer PLA Dissolved in 10 times the weight of the volatile solvent dichloromethane to obtain solution 1, cooled to below 20°C;
[0054]2) Mix an aqueous solution containing 8% (wt / wt) emulsifier Tween 80 equivalent to 3 times the volume of solution 1 with solution 1 to make an emulsion;
[0055] 3), evaporate the volatile solvent in the above-mentioned e...
Embodiment 2
[0089] Its composition (formulation) is as follows:
[0090]
[0091] Among them, L-polylactic acid : The weight average molecular weight is 130,000 to 160,000, and the (average) particle size is 20 to 40 microns;
[0092] Poly-lactide-glycolide (1:2) : The weight-average molecular weight is 0.6-0.8 million, and the (average) particle size is 10-15 microns;
[0093] Lidocaine particles have a (average) particle size of 5 nm to 20 nm;
[0094] The average molecular weight of polygelatin is 180,000-250,000.
[0095] Preparation:
[0096] Same as Example 1.
Embodiment 3
[0098] Its composition (formulation) is as follows:
[0099]
[0100] Among them, L-polylactic acid : The weight average molecular weight is 130,000 to 160,000, and the (average) particle size is 20 to 40 microns;
[0101] Poly-lactide-glycolide (1:2) : The weight-average molecular weight is 0.6-0.8 million, and the (average) particle size is 10-15 microns;
[0102] Lidocaine particles have a (average) particle size of 5 nm to 20 nm;
[0103] The average molecular weight of polygelatin is 27500-39500.
[0104] Preparation:
[0105] Same as Example 1.
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