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Preparation method and application of fructus lycii polysaccharide-chromium complex

A technology of lycium barbarum polysaccharide and chromium complex, applied in the field of medicine, can solve the problems such as the result that the effect cannot be achieved, and achieve the effects of high development value, no adverse reaction and convenient production

Inactive Publication Date: 2017-11-28
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the past, inorganic chromium salt preparations were used to supplement, but the results could not achieve the desired effect

Method used

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  • Preparation method and application of fructus lycii polysaccharide-chromium complex
  • Preparation method and application of fructus lycii polysaccharide-chromium complex
  • Preparation method and application of fructus lycii polysaccharide-chromium complex

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Embodiment 1

[0030] 1 Purification of Lycium barbarum polysaccharide

[0031] (1) Preparation of phosphate buffer:

[0032] Liquid A: accurately weigh 3.121g sodium dihydrogen phosphate dihydrate, and a 100mL volumetric flask has a constant volume;

[0033] Liquid B: accurately weigh 1.764g disodium hydrogen phosphate dodecahydrate, and a 100mL volumetric flask has a constant volume;

[0034] Buffer: mix 39.0ml of A solution and 61.0ml of B solution, pH=7.0;

[0035] (2) Preparation of enzyme solution:

[0036] Accurately weigh 0.1g trypsin, 10mL in phosphate buffer, and dissolve in a 37°C water bath to obtain a 10mg / mL trypsin solution;

[0037] (3) Dialysis bag treatment: place the dialysis bag in 2wt% NaHCO 3 Boil the mixture with 1mmol / L EDTA (pH=8) for 10 minutes, wash with distilled water, then boil with 1mmol / L EDTA (pH=8) for 10 minutes, cool and place in a refrigerator at 4°C for standby; dialysis bag handling requires gloves , Make sure the dialysis bag is immersed in the preservation solut...

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Abstract

The invention discloses a preparation method and application of fructus lycii polysaccharide-chromium complex. In the fructus lycii polysaccharide-chromium complex, mass fraction of chromium is 5-7%. Purified fructus lycii polysaccharide and chromium are self-assembled to react to form complex under certain condition, and the complex is separated and purified to obtain the fructus lycii polysaccharide-chromium complex. According to the animal activity test, the fructus lycii polysaccharide-chromium complex remarkably reduce hypoglycemic action of hyperglycemic mice, and the hypoglycemic action reduction is higher than that of inorganic chromium and fructus lycii polysaccharide, and is further superior to that of glibenclamide under certain dose. Therefore, the fructus lycii polysaccharide-chromium complex can be used for preparing an antidiabetic drug and healthcare food.

Description

Technical field [0001] The invention relates to a preparation method and application of a wolfberry polysaccharide-chromium complex, and belongs to the field of medicine. Background technique [0002] Diabetes is a disease that seriously threatens human life and health. The world is committed to the research and development of new diabetes drugs. Finding effective, safe, and less adverse reactions to treat diabetes has always been the goal of drug developers. Finding drugs from natural medicines The active ingredient of blood sugar is an important way. Polysaccharides have immunoregulatory, anti-tumor, hypoglycemic, and antioxidant effects. Lycium barbarum is a traditional Chinese medicine for both medicine and food, which has a good function of lowering blood sugar. Lycium barbarum polysaccharide is the functional active ingredient. Lycium barbarum polysaccharide can significantly decrease the level of ascorbic acid and SOD activity in the retina of diabetic rats, and increase...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61K33/24A61P3/10
CPCA61K31/715A61K33/24C08B37/0003C08B37/006A61K2300/00
Inventor 李清禄庾慧李宇翔
Owner FUJIAN AGRI & FORESTRY UNIV
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