Prediction method and application of three-dimensional dose distribution in intensity-modulated radiotherapy planning

Abstract

The invention discloses a predication method for three-dimensional dose distribution in intensity modulated radiation therapy plans. The method includes steps of (1) collecting valid intensity modulated radiation therapy plan data and forming a case database; (2) dividing a PTV and different to-be-endangered organs of patients into a plurality of voxels according to the resolution ratio of CT images; (3) extracting anatomical characteristics of each patient in the database; (4) extracting dose characteristics of each patient in the database; (5) constructing an artificial neural network, inputting the anatomical characteristics and the dose characteristics of the patients, and learning the mapping relation between the anatomical characteristics and the dose characteristics by the aid of the artificial neural network, and obtaining a correlation model of the anatomical characteristics and the dose characteristics; (6) using the correlation model to predicate the three-dimensional dose distribution of a new patient. The application of said method is using the dose distribution predication method for dose prediction for to-be-endangered organs of patients and quality control is achieved. By adopting the above method, predication of three-dimensional dose distribution in intensity modulated radiation therapy plans can be realized and the method can be applied to a quality control link.

Description

technical field

[0001] The invention relates to the technical field of medical radiotherapy, in particular to a method for predicting three-dimensional dose distribution in an intensity-modulated radiotherapy plan and specific applications of the method. Background technique

[0002] Tumor radiation therapy uses radiation to kill tumor cells and avoid normal tissues and endangered organs from being irradiated as much as possible. It is one of the main methods for treating malignant tumors. The key to improving the quality of radiotherapy is to achieve a high concentration of beam energy on the tumor area. In terms of radiotherapy technology, the intensity-modulated radiotherapy technology, that is, the intensity-modulated technology, further improves the conformity of the dose distribution in the patient's body through the movement of the multi-leaf grating and the adjustment of the beam intensity. Mainstream treatment for internal and other types of tumors.

[0003] Clini...

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