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Determination method for detecting fat-soluble coloring agent in paper for cigarettes by utilizing ultra-performance liquid chromatography-tandem mass spectrometry

A technology of ultra-high performance liquid chromatography and tandem mass spectrometry, which is applied in the field of direct determination of ultra-high performance liquid chromatography-tandem mass spectrometry, which can solve problems such as difficult separation, many types of colorants, and large matrix interference, and achieve good impurity interference and pretreatment methods Simple, highly resistant to matrix interference

Inactive Publication Date: 2017-12-19
CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods have a lot of matrix interference, and there are many kinds of colorants, so it is difficult to completely separate them. Liquid chromatography-tandem mass spectrometry can overcome such problems by using the multi-reaction ion monitoring mode.

Method used

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  • Determination method for detecting fat-soluble coloring agent in paper for cigarettes by utilizing ultra-performance liquid chromatography-tandem mass spectrometry
  • Determination method for detecting fat-soluble coloring agent in paper for cigarettes by utilizing ultra-performance liquid chromatography-tandem mass spectrometry
  • Determination method for detecting fat-soluble coloring agent in paper for cigarettes by utilizing ultra-performance liquid chromatography-tandem mass spectrometry

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0033] 1. Instruments and reagents:

[0034] Fat-soluble colorants, acetonitrile and acetone are chromatographic grade reagents; they meet the requirements of first-grade water in GB / T 6682.

[0035] Waters TQS quadrupole tandem mass spectrometer; Swiss Mettler AE 163 electronic balance (sensitivity: 0.0001g).

[0036] 2. Sample handling:

[0037] Weigh 0.5 g carton packing paper sample (accurate to 0.01 g), and place it in a 50 mL Erlenmeyer flask with a stopper. Accurately add 20mL extract: acetone, ultrasonically extract for 30 min; sample purification: stand still for 5 min, pipette 1.5 mL extract into a 2 mL centrifuge tube (containing 25 mg neutral alumina), vortex at 2000 rpm After 2 minutes, centrifuge at 8000 rpm for 5 minutes. Aspirate 1mL of the supernatant, blow it nearly dry with nitrogen, reconstitute with 1mL of acetonitrile, and filter through a 0.22μm organic phase filter. Pipette 200 μL of the filtrate, dilute the sample to 1.0 mL with acetonitrile, and...

example 2

[0042] According to the method described in Example 1, another tipping paper sample for cigarettes was selected, and no fat-soluble coloring agent was detected in the sample.

example 3

[0044] According to the method described in Example 1, another cigarette paper sample was selected, and no fat-soluble colorant was detected in the sample.

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Abstract

The invention belongs to the technical field of physical and chemical inspection of harmful substance residues in paper for cigarettes and in particular relates to a determination method for detecting a fat-soluble coloring agent in the paper for cigarettes; the determination method is characterized by comprising the following steps: firstly, shearing the paper for cigarettes; carrying out ultrasonic extraction; after carrying out extraction and purification on a dispersed solid phase of an extracting solution and centrifuging, directly filtering and determining the fat-soluble coloring agent in paper sheets by utilizing an ultra-performance liquid chromatography-tandem mass spectrometry. The method provided by the invention can be used for rapidly and accurately detecting the residues of the fat-soluble coloring agent in the paper for cigarettes; the method has the advantages of environment protection, accurate result, few interferences, high sensitivity and good repeatability.

Description

technical field [0001] The invention belongs to the technical field of physical and chemical inspection of harmful substance residues in cigarette paper, and mainly relates to a method for measuring fat-soluble colorants in cigarette paper, tipping paper, carton wrapping paper, and cigarette paper, and specifically adopts an ultrasonic method Extract fat-soluble colorants, disperse solid-phase extraction and clean up, and use ultra-high performance liquid chromatography-tandem mass spectrometry for direct determination. Background technique [0002] Synthetic colorants are mainly made of aromatic chemical products such as benzene, toluene, naphthalene, etc., and are compounded through a series of organic reactions such as sulfonation, nitration, halogenation, and azolation. They have no nutritional value themselves, but due to their low cost , Bright color, strong tinting power, stable properties and convenient color matching, can increase the sensory beauty of food and impr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88G01N30/06
CPCG01N30/06G01N30/88G01N2030/062G01N2030/884
Inventor 杨飞邓惠敏王颖刘珊珊李中皓范子彦边照阳唐纲岭
Owner CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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