Up-attraction magnetic bead transferring mechanism and magnetic bead transferring method thereof

Abstract

The invention discloses an up-attraction magnetic bead transferring mechanism and a magnetic bead transferring method thereof. The magnetic bead transferring mechanism comprises a horizontally-movable incubation chamber, a reagent strip, a magnetic bar sleeve and an extraction gun. The reagent strip is put in the incubation chamber and provided with a plurality of pores; the magnetic bar sleeve is put in one of the pores; the extraction gun is positioned above the magnetic bar sleeve and capable of moving up and down and comprises an extraction gun head and a permanent magnet, the extraction gun head can be in interference fit with the magnetic bar sleeve, the permanent magnet is positioned on the axis of the extraction gun head, used for attracting magnetic beads and driven by an extraction motor to move up and down relative to the extraction gun head. By the up-attraction magnetic bead transferring mechanism, reliability and stability in transferring of the magnetic beads are improved, and the fault rate is decreased due to freeness of fluid circuit design. A chemiluminescence immunoassay instrument with the up-attraction magnetic bead transferring mechanism is capable of stably and reliably transferring the magnetic beads into samples, washing liquor or reagents, and integral performances of the chemiluminescence immunoassay instrument are guaranteed.

Description

technical field [0001] The invention relates to the field of chemiluminescence immunoassay, in particular to an up-suction magnetic bead transfer mechanism and a magnetic bead transfer method thereof. Background technique [0002] Chemiluminescent immunoassay has the advantages of high sensitivity, strong specificity, wide linear range, and high degree of automation, and has become the main means of clinical diagnosis. However, domestic automatic chemiluminescence immunoassays started relatively late, and clinical applications developed rapidly. At first, only test items such as sex hormones and thyroid hormones were detected by chemiluminescence. With the further development of technology, tumor markers, metabolic substances, There are more and more detectable items such as infectious disease markers and cardiovascular and cerebrovascular disease markers. At the same time, chemiluminescence immunoassay also has its uncertainties, which mainly come from the experimental oper...

AI Technical Summary

Problems solved by technology

[0005] But in such figure 1 When filling liquid into the container as shown in c, the magnetic beads cannot be washed away because the injection needle is not aligned with the magnetic beads or the impact force of the liquid is not enough, such as figure 1 As shown in e, this will lead to insufficient washing of the magnetic beads, or insufficient reaction between the magnetic beads and the sample or labeling reagent; figure 1 As shown in f, it will lead to the problem that the magnetic beads cannot be washed, or the magnetic beads cannot react with the sample or labeling reagent

[0006] In addition, the transfer of magnetic beads on the existing chemiluminescence immunoassay analyzer requires a pipetting liquid circuit and a liquid addition liquid circuit. The liquid circuit is relatively complicated, and the liquid circuit is the most prone to failure on the chemiluminescence immunoassay analyzer.

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