Hypertonic polysaccharide bio-hydrogel dressing and preparation method thereof

A high-osmotic polysaccharide and hydrogel technology, applied in medical science, bandages, etc., can solve the problems of easy growth of wound granulation tissue, no obvious promotion of wound healing, and inability to keep the wound moist, so as to inhibit the migration of bacteria and reduce Exudation and inflammatory response, reducing wound adhesion

Inactive Publication Date: 2018-01-05
任汉学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the 1960s, most of the wound dressings used for more than half a century were gauze. Gauze was mostly processed from cotton, soft burlap and linen. It was an inert dressing, and its design concept was to absorb, eliminate wound exudate and isolate the wound. No effect on wound healing
The research on dressing materials is also mainly considered from the aspects of biological inertia, non-toxicity and biocompatibility. However, dressings of this structure create a drier environment on the wound surface and dehydrate the wound surface. Scabs have obvious obstacles to the epithelialization of wounds, and their shortcomings are also very prominent, such as: (1) the wound cannot be kept moist, and wound healing is delayed; (2) the dressing fibers are easy to fall off, causing foreign body reactions and affecting healing; (3) Granulation tissue is easy to grow into the mesh of the dressing, which can cause pain when changing the dressing; (4) When the dressing is soaked, pathogens can easily pass through; (5) When changing the dressing, it is easy to damage the new tissue; (6) The workload of changing the dressing is heavy

Method used

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  • Hypertonic polysaccharide bio-hydrogel dressing and preparation method thereof
  • Hypertonic polysaccharide bio-hydrogel dressing and preparation method thereof
  • Hypertonic polysaccharide bio-hydrogel dressing and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] The hyperosmotic polysaccharide biological hydrogel dressing that this embodiment relates to comprises the following components by weight percentage:

[0032]

[0033] Its preparation method is:

[0034] Add high-viscosity carboxymethylcellulose into distilled water, stir evenly at room temperature at a speed of 200-300rpm, and use it as the first component;

[0035] Add medium-viscosity carboxymethyl cellulose into the first component at room temperature, and stir evenly at a speed of 100-300 rpm as the second component;

[0036]Sprinkle the low-viscosity carboxymethyl cellulose on the surface of the second component at room temperature, after standing still, use a homogenizer at a speed of 2000-3000rpm for 7-10 minutes, and then at a speed of 400-600rpm Stir until evenly dispersed, as the third component;

[0037] Add sodium chloride to the third component, homogenize at 7000-8000 rpm for 10-20 minutes, and then discharge.

Embodiment 2

[0039] The hyperosmotic polysaccharide biological hydrogel dressing that this embodiment relates to comprises the following components by weight percentage:

[0040]

[0041] Its preparation method is:

[0042] Add high-viscosity carboxymethylcellulose into distilled water, stir evenly at room temperature at a speed of 200-300rpm, and use it as the first component;

[0043] Add medium-viscosity carboxymethyl cellulose into the first component at room temperature, and stir evenly at a speed of 100-300 rpm as the second component;

[0044] Sprinkle the low-viscosity carboxymethyl cellulose on the surface of the second component at room temperature, after standing still, use a homogenizer at a speed of 2000-3000rpm for 7-10 minutes, and then at a speed of 400-600rpm Stir until evenly dispersed, as the third component;

[0045] Add sodium chloride to the third component, homogenize at 7000-8000 rpm for 10-20 minutes, and then discharge.

Embodiment 3

[0047] The hyperosmotic polysaccharide biological hydrogel dressing that this embodiment relates to comprises the following components by weight percentage:

[0048]

[0049] Its preparation method is:

[0050] Add high-viscosity carboxymethylcellulose into distilled water, stir evenly at room temperature at a speed of 200-300rpm, and use it as the first component;

[0051] Add medium-viscosity carboxymethyl cellulose into the first component at room temperature, and stir evenly at a speed of 100-300 rpm as the second component;

[0052] Sprinkle the low-viscosity carboxymethyl cellulose on the surface of the second component at room temperature, after standing still, use a homogenizer at a speed of 2000-3000rpm for 7-10 minutes, and then at a speed of 400-600rpm Stir until evenly dispersed, as the third component;

[0053] Add sodium chloride to the third component, homogenize at 7000-8000 rpm for 10-20 minutes, and then discharge.

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Abstract

The invention discloses a hypertonic polysaccharide bio-hydrogel dressing. The hypertonic polysaccharide bio-hydrogel dressing comprises the following components by weight percentage: high viscosity carboxymethyl cellulose, medium viscosity carboxymethyl cellulose, low viscosity carboxymethyl cellulose, sodium chloride, and the balance water. The invention has the advantages that: polysaccharide has extensive pharmacological action and relatively low toxicity, and therefore receives attention of more and more researchers, in a wound repair process, soluble oxidized polysaccharide not only canplay certain anti-inflammatory role, but also has great promoting effect on the tissue repair process. Compared with the traditional oil gauze dressing, the "tissue wound closing" material has incomparable superiority, can maintain a moist environment, reduce various wound exudation and inflammatory reactions, and reduce dressing and wound adhesion, thus shortening the wound healing time and reducing the infection rate.

Description

technical field [0001] The invention relates to a hyperosmotic polysaccharide biological hydrogel dressing and a preparation method thereof, belonging to the technical field of wound medicine. Background technique [0002] For more than a century, western medicine has mainly treated wounds (skin) by applying dressings to cover wounds. In theory, wound dressings can prevent microbial contamination of wounds and prevent infection from spreading to other patients. In clinical applications, dressings also mainly play a role as a barrier . Furthermore, the composition and characteristics of the dressing itself can play a role in regulating the microenvironment of the wound. In the 1960s, most of the wound dressings used for more than half a century were gauze. Gauze was mostly processed from cotton, soft burlap and linen. It was an inert dressing, and its design concept was to absorb, eliminate wound exudate and isolate the wound. It has no obvious promoting effect on wound hea...

Claims

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Application Information

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IPC IPC(8): A61L26/00
Inventor任汉学
Owner任汉学