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A kind of acid-resistant pullulan derivative and preparation method thereof

A pullulan polysaccharide and derivative technology, applied in the chemical industry, can solve problems such as easy dissolution

Active Publication Date: 2020-08-11
INST OF MICROBIOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention provides an acid-resistant pullulan derivative and a preparation method thereof in order to solve the technical problem that existing products are easily dissolved under acidic conditions

Method used

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  • A kind of acid-resistant pullulan derivative and preparation method thereof
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  • A kind of acid-resistant pullulan derivative and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 15g pullulan, 30g phthalic anhydride, 55g pyridine, 105ml N,N-dimethylformamide. When the temperature rose to 80°C, the reaction time was started for 12 hours. After the reaction was completed, the reaction solvent was evaporated in a vacuum rotary, and the product was poured into ice water for washing. Wash repeatedly until the washing solution is neutral. Filter to obtain wet product, freeze-dry to obtain product. The structural infrared characterization of the product is as follows figure 1 As shown, the mass percentage of formyl benzoate is 35%, and the pullulan derivative remains intact at low pH (pH=1.5-4), and dissolves at higher pH (pH=5-7).

Embodiment 2

[0031] 15g pullulan, 10g phthalic anhydride, 25g pyridine, 35ml N,N-dimethylformamide. When the temperature rose to 50°C, the reaction time was started for 48h. After the reaction was completed, the reaction solvent was evaporated in a vacuum rotary, and the product was poured into ice water for washing. Wash repeatedly until the washing solution is neutral. Filter to obtain a wet product, and dry at 40°C to obtain a product. The mass percentage of formyl benzoate is 21%, and the pullulan derivative remains intact at low pH (pH=1.5-4.5), and dissolves at higher pH (pH=5-7).

Embodiment 3

[0033] 15g pullulan, 70g phthalic anhydride, 200g triethylamine, 250ml N,N-dimethylformamide. When the temperature rose to 60°C, the reaction time was started for 24h. After the reaction, the reaction solvent was evaporated in a vacuum rotary, and the product was poured into ice water for washing. Wash repeatedly until the washing solution is neutral. Filter to obtain wet product, freeze-dry to obtain product. The mass percentage of formyl benzoate is 65%, and the pullulan derivative remains intact at low pH (pH=1.5-5), and dissolves at higher pH (pH=5-7).

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Abstract

The invention relates to an acid-resistant Pulullan derivative, and a preparation method thereof. The preparation method is used for solving a technical problem that a conventional product is easily dissolved at acidic conditions. The invention also discloses the structural formula and a preparation method of the acid-resistant Pulullan derivative. The preparation method can be widely used for preparation of acid-resistant Pulullan derivatives.

Description

technical field [0001] The invention relates to the field of chemical industry, in particular to an acid-resistant pullulan derivative and a preparation method thereof. Background technique [0002] Pullulan is an exopolysaccharide produced by the fermentation of Pacillus sporogenes. It is a maltotriose combined with α-1,4 glycosidic bonds, and the two ends are repeatedly connected with another maltotriose with α-1,6 glycosidic bonds. Synthetic polymer linear polysaccharides. Pullulan polysaccharide is safe, non-toxic, non-immunogenic, non-teratogenic, and has many advantages such as good biocompatibility and biodegradability. It is an excellent biological material used in drug delivery systems and biological tissue engineering and other fields. [0003] Pullulan polysaccharide has good film-forming properties, and the gas permeability of film-forming is low, and gases such as oxygen, nitrogen, and carbon dioxide can hardly pass through, so it is used in the preparation of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/02
Inventor 高启合晏礼明
Owner INST OF MICROBIOLOGY - CHINESE ACAD OF SCI
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