Pharmaceutical composition having effect of improving blood circulation as well as application of pharmaceutical composition and injection prepared and formed by pharmaceutical composition

A technology for improving blood circulation and composition, which is applied in the direction of medical preparations containing active ingredients, drug combinations, ether/acetal active ingredients, etc., can solve the problem that ginkgo biloba extract and its preparations are difficult to meet quality requirements, cannot To ensure the safety of medication, the active ingredients are not clear, etc., to achieve the effect that is beneficial to clinical use, suitable for industrial production, and clear ingredients

Inactive Publication Date: 2018-01-12
朗致集团江西医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] Therefore, the technical problem to be solved by the present invention is to overcome the defect that the Ginkgo biloba extract and its preparations prepared by the prior art are difficult to meet the quality requirements and cannot g

Method used

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  • Pharmaceutical composition having effect of improving blood circulation as well as application of pharmaceutical composition and injection prepared and formed by pharmaceutical composition
  • Pharmaceutical composition having effect of improving blood circulation as well as application of pharmaceutical composition and injection prepared and formed by pharmaceutical composition
  • Pharmaceutical composition having effect of improving blood circulation as well as application of pharmaceutical composition and injection prepared and formed by pharmaceutical composition

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Embodiment 1

[0045] The present invention provides a kind of preparation method of the injection of the pharmaceutical composition that has effect of improving blood circulation, comprises the following steps:

[0046] (1) After getting Ginkgo biloba pulverization, add 95% ethanol and reflux extraction 3 times, each reflux extraction time is 0.5 hour, the quality that adds 95% ethanol at every turn is 10 times of described Ginkgo leaf quality; Filter, the gained filtrate Concentrate under reduced pressure to 0.2 times the mass of ginkgo leaves, and refrigerate for 48 hours;

[0047] (2) Scrape off the slick oil and take off the lower layer liquid;

[0048] (3) Add water for injection to 0.5 times of the quality of ginkgo leaves in the lower layer liquid, and refrigerate for 48 hours; filter, concentrate the filtrate under reduced pressure to 0.2 times of the quality of ginkgo leaves, put to room temperature, add 95% ethanol, make the alcohol content to 80%, the solution after alcohol prec...

Embodiment 2

[0053] The present invention provides a kind of preparation method of the injection of the pharmaceutical composition that has effect of improving blood circulation, comprises the following steps:

[0054] (1) After getting Ginkgo biloba pulverization, add 97% ethanol and reflux extraction 4 times, each reflux extraction time is 0.7 hour, the quality that adds 97% ethanol at every turn is 11.5 times of described Ginkgo leaf quality; Filter, the gained filtrate Concentrate under reduced pressure to 0.25 times the mass of Ginkgo biloba leaves, and refrigerate for 51 hours;

[0055] (2) Scrape off the slick oil and take off the lower layer liquid;

[0056] (3) Add water for injection to 0.4 times of the quality of ginkgo leaves in the lower layer liquid, and refrigerate for 45 hours; filter, concentrate the filtrate under reduced pressure to 0.25 times of the quality of ginkgo leaves, put to room temperature, add 97% ethanol, make the alcohol content to 82%, the solution after a...

Embodiment 3

[0061] The present invention provides a kind of preparation method of the injection of the pharmaceutical composition that has effect of improving blood circulation, comprises the following steps:

[0062] (1) After getting Ginkgo biloba and pulverizing, add 98% ethanol and reflux extraction 5 times, each reflux extraction time is 0.6 hour, the quality that adds 98% ethanol at every turn is 9.5 times of described Ginkgo biloba quality; Filter, the gained filtrate Concentrate under reduced pressure to 0.15 times the mass of ginkgo leaves, and refrigerate for 45 hours;

[0063] (2) Scrape off the slick oil and take off the lower layer liquid;

[0064] (3) Add water for injection to 0.6 times of the quality of ginkgo leaves in the lower layer liquid, and refrigerate for 51 hours; filter, concentrate the filtrate under reduced pressure to 0.15 times of the quality of ginkgo leaves, put to room temperature, add 98% ethanol, make the alcohol content to 78%, the solution after alcoh...

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Abstract

The invention belongs to the field of pharmaceutical compositions, and in particular relates to a pharmaceutical composition having an effect of improving blood circulation as well as an application of the pharmaceutical composition and an injection prepared and formed by the pharmaceutical composition. The pharmaceutical composition consists of total flavonoid glycosides and ginkgolide extractedfrom folium ginkgo, and on the basis of the various components which are mutually cooperated, the pharmaceutical composition can be clinically applicable to improvement of blood circulation; more importantly, the pharmaceutical composition, which contains pinitol and sequoyitol at specific proportions, is more excellent than an existing Shuxuening injection in efficacy; and moreover, the pharmaceutical composition is clear in ingredients and controllable in mass, so that curative effect and administration safety are guaranteed. The invention also provides a preparation method of the pharmaceutical composition; by conducting reflux extraction with 95-98% ethanol, and by sequentially implementing cation and anion resin adsorption treatment, the components can be effectively separated; and the preparation method is simple in process and applicable to industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions, and in particular relates to a pharmaceutical composition with the effect of improving blood circulation, its application and an injection prepared therefrom. Background technique [0002] Blood circulation diseases are common diseases that affect human health. Patients manifest symptoms such as hyperlipidemia, hyperglycemia, cerebral thrombosis, arteriosclerosis, memory loss, insomnia, anemia, fatigue, osteoporosis, and hypoxia. [0003] Among the many methyl derivatives of inositol, D-Pinitol and 5-O-methyl-myoinositol (also known as Sequoyitol) are the two most common methyl derivatives. Ohmoto et al. isolated pinitol and paclitaxel from ginkgo pollen particles in 1980. The molecular structures of pinitol and paclitaxel are shown in formula (I) (II) respectively: [0004] [0005] In recent years, pinitol and paclitaxel have become research hotspots, and more and more functional...

Claims

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Application Information

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IPC IPC(8): A61K31/075A61K31/365A61K31/7048A61K36/16A61K9/08A61P9/00
Inventor 王锋杨满辉
Owner 朗致集团江西医药有限公司
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