Method for separation and enrichment of furoquinoline alkaloid in dictamnus angustifolius

A technology of furoquinoline and white fresh skin, applied in the direction of organic chemistry, etc., can solve the problems of cumbersome operation, serious pollution, low efficiency, etc.

Inactive Publication Date: 2018-01-26
CHINA PHARM UNIV
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Problems solved by technology

[0004] The invention provides a method for isolating furanoquinoline alkaloids from Cortex angustifolia in combination with the prior art, which solves the shortcomings of traditional methods such as high cost, serious pollution, cumbersome operation, low efficiency, and difficult purification.

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  • Method for separation and enrichment of furoquinoline alkaloid in dictamnus angustifolius
  • Method for separation and enrichment of furoquinoline alkaloid in dictamnus angustifolius
  • Method for separation and enrichment of furoquinoline alkaloid in dictamnus angustifolius

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Embodiment Construction

[0044] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments.

[0045] figure 1 It is the implementation flow of the method for separating and enriching furanoquinoline alkaloids from the fresh bark of Diana angustifolia provided by the embodiment of the present invention. It mainly includes the following 4 steps:

[0046] Extraction: Take 10Kg of crushed white fresh bark, add 25L of 85% ethanol solution, soak at room temperature for 6 hours, heat and reflux for extraction for 4 hours, filter, collect the filtrate, add 25L of 85% ethanol solution to the filter residue, heat and reflux for 3 hours, repeat the above operation , a total of 3 times of heating and reflux extraction, the heating time is 4h, 3h, 3h respectively. The three filtrates were combined and concentrated to extract 565g of dry extract. ...

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Abstract

The invention relates to a method for separation and enrichment of furoquinoline alkaloid, wherein the method is characterized by comprising the steps: carrying out heating reflux extraction of crushed dictamnus angustifolius for 3 times with an ethanol solution, filtering, merging the filtrates, concentrating, then respectively extracting with petroleum ether, dichloromethane and ethyl acetate, selecting a dichloromethane extraction part, using a silica column chromatography, Sephadex LH-20, preparative HPLC, recrystallization and other separation purification methods, and separating and enriching the furoquinoline alkaloid. The method has the advantages of high efficiency, low pollution and relatively low cost and has strong popularization and application value.

Description

Technical field: [0001] The invention belongs to the field of separation of natural products, and in particular relates to a method for separating and enriching furan-quinoline alkaloids from fresh bark of P. angustifolia. Background technique: [0002] Narrow leaf white fresh skin, also known as Xinjiang white fresh skin, belongs to the perennial herbaceous plant of Rutaceae white fresh, is a unique Chinese medicinal material in my country, and is often used as a substitute for traditional Chinese medicine white fresh in Xinjiang. It has a bitter taste and a cold nature. It has the effects of clearing away heat and detoxification, expelling wind and dampness, killing insects and relieving itching. The root bark is mostly used in the treatment of rheumatism, bleeding, itching, jaundice, chronic hepatitis, skin diseases and other diseases, and as an anti-inflammatory agent, antipyretic and detoxification. In fact, there are two main types of active ingredients in the fresh b...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D491/048
Inventor 孙建博李强强王兵
Owner CHINA PHARM UNIV
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