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A kind of compound hedyotis diffusa granule and preparation method thereof

A technology of Hedyotis diffusa and granules, which can be applied to medical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., and can solve the problems of cumbersome decoction, bitter taste, and inconvenient carrying.

Active Publication Date: 2021-07-09
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The compound Hedyotis diffusa was first used as a decoction of traditional Chinese medicine, which has problems such as cumbersome decoction, bitter taste, and inconvenient carrying.
At present, there are patent reports on the traditional Chinese medicine composition of Hedyotis diffusa, Scutellaria barbata, Astragalus and malt or their extracts and their uses. It has the purpose of preventing and treating cancer. The traditional Chinese medicine composition powder of the above-mentioned patent also has the problems of bitter taste and inconvenient carrying.

Method used

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  • A kind of compound hedyotis diffusa granule and preparation method thereof
  • A kind of compound hedyotis diffusa granule and preparation method thereof
  • A kind of compound hedyotis diffusa granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The raw materials and equipment used in the specific embodiment of the present invention are all known products, obtained by purchasing commercially available products. Embodiment 1, the preparation of compound Hedyotis diffusa granule of the present invention

[0029] Take 20g of Hedyotis diffusa, 20g of Scutellaria barbata, 20g of Astragalus membranaceus, and 20g of malt, add 10 times the amount of water of raw materials and soak for 1 hour, heat to reflux, extract twice for 1 hour each time, filter, and combine the filtrates. Concentrate to a thick paste with a relative density of 1.15-1.20, dry to constant weight, cool, and pulverize the extract into fine powder.

[0030] Get above-mentioned extract fine powder 480g, add 400g soluble starch and 80g dextrin, 4.8g cyclamate, mix well, add 100ml PVP-90% v / v ethanol solution (wherein, the amount of PVP in 100ml solution is 5g), dry , granulation, that is, anti-tumor granules.

Embodiment 2

[0031] Embodiment 2, the process screening of preparing compound Hedyotis diffusa granules

[0032] 1 Concentration process research

[0033] ①Atmospheric pressure concentration method

[0034] Take the filtrate obtained in Example 1, put it in a constant weight beaker, put it into a water bath with a temperature of 100° C., and concentrate it to a thick paste with a relative density of 1.15-1.20.

[0035] ②Concentrated relative density investigation

[0036] Take the spare medicinal liquid (120mL) under item ①, and divide it into 3 equal portions, each 40mL. Concentrate in a water bath until it is concentrated to about 10mL, observe its state, and measure the relative density by the method under item ① until it reaches a viscous and wall-hanging state. (relative density=extract actual density / pure water density), concentration degree results are shown in Table 1

[0037] Table 1 Concentration degree results investigation table

[0038] Liquid volume (mL) stat...

Embodiment 3

[0049] Example 3, preparation of auxiliary material screening of compound Hedyotis diffusa granules

[0050] 1 Screening of filler types

[0051] According to the five factors of investigating compound Hedyotis diffusa granule molding rate, angle of repose, bulk density, moisture absorption rate and observed properties, evaluate and optimize the optimal filler for compound Hedyotis diffusa granule, and the auxiliary materials are obtained from Example 1 See Table 3 for the compatible prescription of extract fine powder.

[0052] Table 3 Compatible prescriptions of different fillers and extract fine powder

[0053] 1 2 3 4 5 6 7 Extract powder (g) 5 5 5 5 5 5 5 Soluble starch (g) 5 Lactose (g) 5 Mannitol (g) 5 Microcrystalline Cellulose (g) 5 Sucrose (g) 5 Dextrin (g) 5

[0054] ① Formability inspection

[0055] Weigh 10 g of the prepar...

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Abstract

The invention provides a compound hedyotis diffusa granule, which is composed of the following raw materials in the following weight ratio: 480 parts of extract, 480 parts of filler, 5-15 parts of corrective agent, and 5 parts of binder; Wherein, the extract is prepared by the following method: weighing the raw materials of Hedyotis diffusa, Scutellaria barbata, Radix Astragali, and malt according to equal weight proportions, and extracting them with water. The present invention also provides a preparation method of compound Hedyotis diffusa granules, the steps are as follows: Weigh the raw materials of Hedyotis diffusa, Scutellaria barbata, Astragalus membranaceus, and malt according to equal weight proportions, extract with water, and obtain the extracted Add fillers, correctives, mix evenly, granulate with binder and 90% V / V ethanol, and get ready. The invention also provides the application of the compound hedyotis diffusa granule. The compound hedyotis diffusa granule provided by the invention has good taste and is convenient to carry.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to a compound hedyotis diffusa preparation and a preparation method thereof. Background technique [0002] Hedyotis diffusa Willd. (Hedyotis diffusa Willd.) is a plant of the genus Auricularia in the Rubiaceae family. The whole herb is used as medicine. Scutellaria barbata is the dried whole herb of Scutellaria barbata D.Don., a plant of the genus Scutellaria barbata of the Lamiaceae family. Astragalus is the root of the perennial herb Astragalus membranaceus (Fisch.) Bunge and Astragalus membranaceus (A.mongholicus Bge.). Malt is germinated and dried from the mature fruit of the gramineous plant barley (Hordeum vulgare L.). [0003] The compound Hedyotis diffusa was first used as a traditional Chinese medicine decoction, but it has problems such as cumbersome decoction, bitter taste and inconvenient carrying. At present, there are patent reports on...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/8998A61K47/20A61K47/36A61P35/00
Inventor 林久茂李煌彭军林珊魏丽慧
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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