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Anti-inflammatory anti-tumor micro-capsule and preparation method thereof

An anti-tumor and micro-encapsulation technology, applied in anti-tumor drugs, anti-inflammatory agents, micro-capsules, etc., can solve problems such as no reports on the development of IL-37 microcapsules, achieve strong immunosuppressive ability, reduce toxicity, and widen clinical The effect of the application foreground

Inactive Publication Date: 2018-02-02
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the development of IL-37-related microcapsules

Method used

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  • Anti-inflammatory anti-tumor micro-capsule and preparation method thereof

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Embodiment 1

[0031] Anti-inflammatory and anti-tumor microcapsules include polymer microcapsules, which are PGA polyethylene glycol acid layer-collagen layer double-layer semi-permeable membrane structure, the diameter of the microcapsule is 300 μm, and the wall thickness of the microcapsule is 8 μm , 10 IL-37 gene-modified cells are initially wrapped in the microcapsule.

Embodiment 2

[0033] Anti-inflammatory and anti-tumor microcapsules include polymer microcapsules, which are PGA polyethylene glycol acid layer-collagen layer double-layer semi-permeable membrane structure, the diameter of the microcapsule is 400 μm, and the wall thickness of the microcapsule is 6 μm , 11 IL-37 gene-modified cells were initially wrapped in the microcapsule.

Embodiment 3

[0035] Anti-inflammatory and anti-tumor microcapsules include polymer microcapsules, which are PGA polyethylene glycol acid layer-collagen layer double-layer semi-permeable membrane structure, the diameter of the microcapsule is 500 μm, and the wall thickness of the microcapsule is 9 μm , 12 IL-37 gene-modified cells are initially wrapped in the microcapsule.

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Abstract

The invention provides an anti-inflammatory anti-tumor micro-capsule. The anti-inflammatory anti-tumor micro-capsule comprises an IL-37 genetically modified cell and a circular or quasi-circular polymer microcapsule wrapping the IL-37 genetically modified cell, wherein the polymer microcapsule consists of an outer PGA polyethylene glycol acid layer and an inner collagen layer, and has the diameterof 300-600 [mu]m and the wall thickness of 5-10 [mu]m. The anti-inflammatory anti-tumor micro-capsule has the function of releasing streamlined anti-inflammatory molecules IL-37. Compared with pure anti-inflammatory drugs or proteins, the anti-inflammatory anti-tumor micro-capsule can prolong the drug effect, reduce the toxicity and improve the bioavailability, is absorbable and good in toughnessand tensile force, can effectively and continually play the anti-inflammatory anti-tumor role, and rarely produces side effects.

Description

technical field [0001] The invention belongs to a human or animal tissue replacement structure and a preparation method thereof, in particular to an anti-inflammatory and anti-tumor microcapsule and a preparation method thereof. Background technique [0002] Human interleukin-37 (IL-37) is one of the newest members of the interleukin family. It was discovered in 2000 and officially named at the end of 2010. IL-37 is an anti-inflammatory cytokine with a wide range of anti-inflammatory effects, and plays a key role in both limiting the innate inflammation and inhibiting the acquired immune response. In vitro experiments have found that inhibiting the normal expression of IL-37 in human cells will increase the expression and release of inflammatory cytokines induced by IL-1, Toll-link receptor (TRL) and uric acid crystals, including TNF-α, IL-1α, IL-1ß, IL-6 and G-CSF. Human IL-37 is active in mice, although no human equivalent IL-37 gene has been identified in mice so far. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K35/15A61K47/42A61K47/10A61P29/00A61P35/00
CPCA61K35/15A61K9/5031A61K9/5052A61K9/5073
Inventor 王森郭洪胜陈章权黎鹏李淑贤邓子亮
Owner GUANGDONG MEDICAL UNIV
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