The invention discloses a flow distortion simulation device which comprises a tank body, a tube body, a motor, a worm, a bevel gear assembly, a worm gear, a lead screw, a guiding rod, a linear bearing, a gear nut, an inserting plate, a displacement detection assembly and a controller. The tube body is arranged on the tank body, the worm is arranged in the tank body, the bevel gear assembly is respectively connected with the motor and the worm, the worm gear is arranged on the worm, the lead screw is meshed with the worm gear, the linear bearing is arranged on the guiding rod, the gear nut is arranged on the guiding rod and is in screw-thread fit with the lead screw, the inserting plate is respectively connected with the linear bearing and the gear nut, and the controller is respectively connected with the displacement detection assembly and the motor. The flow distortion simulation device has the advantages of being capable of meeting requirements of a turbofan engine inlet distortion resistant test and an engine surge test, small in occupied space, continuous and adjustable in distortion index, convenient to install and operate, high in simulation accuracy and degree of automation, capable of improving the test efficiency, reducing the test cost, reducing the workloads of people and the like.