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Non-invasive detection system for transplanted kidney immune state

A detection system and state technology, which is applied in the direction of organ motion/change detection, ultrasound/sonic/infrasonic Permian technology, medical science, etc. The effect of reducing labor intensity and stable performance

Active Publication Date: 2018-02-16
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above technologies involve more data processing and complicated procedures during the use of doctors, which is not conducive to reducing the burden on the increasingly heavy medical staff. Further automation and semi-automation are needed in diagnostic practice, so that doctors can focus more on case results. Only by analyzing rather than specific process processing and reducing labor intensity can new medical technology solutions be popularized faster
[0004] In summary, there are obviously inconveniences and defects in the actual use of the existing technology, so it is necessary to improve

Method used

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  • Non-invasive detection system for transplanted kidney immune state
  • Non-invasive detection system for transplanted kidney immune state
  • Non-invasive detection system for transplanted kidney immune state

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] Preferred embodiment 1, the non-invasive detection system 100 of the transplanted kidney immune status of the present invention evaluates the immune status of the transplanted kidney within 1 month after operation:

[0105] 1. Patient inclusion

[0106] Patients with acute renal allograft rejection (16 cases), acute tubular necrosis (14 cases) and stable allografted kidney (28 cases) confirmed by renal biopsy were selected. Relevant materials and data are obtained through the Internet through the data management module 10 .

[0107] 2. Calculation of E value

[0108] This step is realized by the first calculation module 31, A1, B1, C1, D1 are taken as -4.222, 2.109, 0.026, 0.043, the calculation process is as follows:

[0109] E=e P / (1+e P )

[0110] where P=-4.222+2.109×SWS–0.026×eGFR+0.043×KC

[0111] SWS is shear wave velocity from elastosonography, eGFR is estimated glomerular filtration rate, and KC is rate of change in graft volume.

[0112] 3. Comparison ...

Embodiment 2

[0114] Preferred embodiment 2, the noninvasive detection system of the transplanted kidney immune status of the present invention evaluates the immune status of the transplanted kidney after one month after operation:

[0115] 1. Patient inclusion

[0116] Patients with acute renal allograft rejection (16 cases), acute tubular necrosis (14 cases) and stable allografted kidney (28 cases) confirmed by biopsy within 1 month after renal transplantation were selected. In addition, patients with acute rejection (41 cases), chronic rejection (25 cases) and stable graft kidney (37 cases) confirmed by renal transplantation biopsy more than 1 month after renal transplantation were selected.

[0117] 2. Calculation of E value

[0118] E=e P / (1+e P )

[0119] where P=-4.222+2.109×SWS–0.026×eGFR+0.043×KC

[0120] SWS is shear wave velocity from elastosonography, eGFR is estimated glomerular filtration rate, and KC is rate of change in graft volume. A1, B1, C1, and D1 are taken as -4...

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Abstract

The invention provides a non-invasive detection system for a transplanted kidney immune state, and belongs to the technical field of post-renal transplantation ultrasonic diagnosis automatics. The non-invasive detection system for the transplanted kidney immune state includes: a data management module for acquiring personal data of a patient and one or more pieces of ultrasonic detection data according to identity recognition information of the patient by means of networking; an ultrasonic connection module for accessing an ultrasonic detector and importing current ultrasonic detection data ofthe transplanted kidney; an analysis processing module for selecting a computing model according to the personal data of the patient, and acquiring an analysis result of the ultrasonic detection data; and a result output module for formatting the analysis result and outputting the result according to the transplanting time of the patient and the analysis processing result. Accordingly, the non-invasive detection system can collect and acquire patient clinical data and ultrasonic detection data, perform automatic / semi-automatic module combination, perform automatic classification operation, and output the image-text integrated result, can lower the working load of doctors, and can facilitate result understanding.

Description

technical field [0001] The invention is suitable for the technical field of ultrasonic diagnosis automation after kidney transplantation, and in particular relates to a non-invasive detection system for the immune state of transplanted kidneys. Background technique [0002] Kidney transplantation is currently the most mature organ transplant operation in the world, with the largest number of operations. After kidney transplantation, patients need to take immunosuppressive agents for life-long anti-rejection therapy. Despite the rapid development of immunosuppressants, rejection and early postoperative acute tubular necrosis (acute tubular injury, ATN) are still inevitable. Acute rejection (acute rejection, AR) can occur at any time after surgery, leading to rapid deterioration of renal function. Chronic rejection (chronic rejection, CR) mainly occurs in the long-term after operation, and is still the key factor restricting the long-term survival of transplanted kidneys. C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B8/08
CPCA61B8/08A61B8/48A61B8/481A61B8/485A61B8/488
Inventor 何婉媛王文平朱同玉杨橙吴盛迪
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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