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Application of il-34 in preparation of medicine for treating or preventing sepsis

A technology for sepsis and drugs, which is applied in the application field of IL-34 in the preparation of drugs for the treatment or prevention of sepsis, can solve the problems of clinical treatment difficulties, lack of medical methods for sepsis bacterial clearance, etc., and achieve the goal of treatment and / or the effect of preventing sepsis

Active Publication Date: 2020-11-24
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinical treatment is very difficult, and the treatment methods are mainly antibacterial treatment and comprehensive treatment for the changes of various systems. At present, there is still a lack of effective medical methods to increase the bacterial clearance rate of sepsis and improve the survival rate of sepsis patients

Method used

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  • Application of il-34 in preparation of medicine for treating or preventing sepsis
  • Application of il-34 in preparation of medicine for treating or preventing sepsis
  • Application of il-34 in preparation of medicine for treating or preventing sepsis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Establishment of sepsis animal model (cecal ligation and puncture, CLP)

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Abstract

The invention provides an application of 1L-34 in preparing drugs for treating or preventing pyaemia. The 1L-34 can significantly improve the collecting ability of macrophage and neutrophile granulocyte, and reach the purpose of treating or preventing pyaemia.

Description

technical field [0001] The invention relates to the technical field of sepsis treatment, in particular to the application of IL-34 in the preparation of medicines for treating or preventing sepsis. Background technique [0002] Sepsis has recently been defined as life-threatening multiple organ failure due to a dysregulated host response to infection. Sepsis is a dangerous condition with a high mortality rate. There have been more than 5 million deaths worldwide, and the morbidity and mortality are still increasing year by year. Although great progress has been made in anti-infection treatment and organ function support technology, the fatality rate of Sepsis is still higher than 25% to 30%, and even as high as 40% to 50% when septic shock occurs. Sepsis treatment costs a lot, consumes a lot of medical resources, seriously affects the quality of life of human beings, and has posed a huge threat to human health. In this regard, the European Intensive Care Society, the Ameri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/20A61K48/00A61K35/12A61P31/04A61P37/04
CPCA61K35/12A61K38/20A61K48/005
Inventor 曹炬林雪颜星星张莉萍
Owner CHONGQING MEDICAL UNIVERSITY